Clomid And Viagra

What have they got in common? They both affect the lining of the uterus.

Clomid: What It Is And How It Works

Clomid was clinically introduced in 1967 as a fertility drug, used primarily in cases of ovulatory disorders. Regularly used very successfully in the treatment of PCOS, this popular and inexpensive fertility drug is commonly used to induce ovulation, correct irregular ovulation, to increase egg production and to correct luteal phase deficiency.

The way in which Clomid works is by influencing the production of the four hormones in a woman's body which affect ovulation, GnRH, FSH, LH and estradiol. A chain reaction occurs as the Clomid tricks the body into believing estrogen levels are low, which in turn triggers the production of gonadotropin releasing hormone (GnRH) within the hypothalamus. This action stimulates the pituitary gland to raise the production level of follicle stimulating hormone (FSH) which causes the ovaries to produce mature follicles. The end result is ovulation which, hopefully would end in conception and a pregnancy.

How Clomid Affects The Endometrium

Clomid is an anti-estrogen and as such has two isomers, or parts. One of the isomers leaves the body within a week after the cessation of Clomid use and the other remains in the system for up to six weeks, acting all the while as an anti-estrogen. The presence of this second isomer in the body has an effect upon the lining of the uterus, causing it to diminish.

Dr. Geoffrey Sher, MD, Executive Medical Director and co-founder of SIRM, and an internationally renowned expert in the field of Assisted Reproductive Therapy, suggests that if a woman has less than three follicles of greater than 15mm and estradiol levels of below 400 pg/ml, she will not develop an adequate lining. He says, "Given the build-up of the anti-estrogen isomer, women who take Clomid for more than three months in a row, regardless of ovarian response, will virtually always have a thin lining. Clomid acts in this way, as a relative contraceptive after three consecutive months of use, regardless of age or ovarian response. This is mainly due to the lining thinning effect."

The Positive Effects Of Viagra On Thinning Endometrium

Enter Viagra. Dr. Sher suggests that Viagra may help in the treatment of thinning endometrium. He says, "Viagra improves blood flow to the uterine lining and thereby improves estrogen delivery." When administered vaginally as a suppository, Viagra has no side-effects, is absorbed locally and reaches the uterus in high concentrations. The increased blood flow encourages the release of nitric oxide in the uterus and because it is gone in 12 hours, there is no further release of nitric oxide afterward. Nitric oxide remnants may be harmful to embryo development and consequently nitro-glycerine is discontinued and the vagina is irrigated to remove all traces of the suppository. The transfer of the fertilized egg to the uterus occurs about a week later, so the danger of nitric oxide in the body is eliminated.

Who would have thought that Clomid and Viagra would appear in the same sentence?

 

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