Is FET the only way?
3 Replies
allison k - August 28


I hope you can answer my questions!

I am currently d/regging for my 7th attempt, having had four fresh IVF (all BFN) and two FET, both positive but sadly m/c.

Since my last m/c I have had many tests, all of which were fine except blood coagulation which showed I have raised Fibirogen levels (4.6 when the highest should be 4). I have also been tested previously for immune issues (all clear) and thrombophilia panel which showed MTHFR, PAI1 and Factor XIII problems (now taking Metformin, high dose folic acid and B vits). The biopsy results on the embryo showed no genetic problems.

I have asked to take Heparin and baby aspirin on my next attempt and also Viagra to help with blood flow (my lining is normally quite thin), all of which I have been told I can take.

The only explaination I have been given for the reasons the fresh attempts don't work (even with Grade 1 blasts) is that some women's bodies just can't handle the drugs and I am worried that I am setting myself up for another failure if I have a fresh transfer on this attempt.

I wondered what your thoughts were on this...

Should I freeze all my embies and go for FET the following month with the Heparin etc as back up?

What is your opinion of why some women can't get pg on fresh attempts but can on FET?

Is the drug regime I have been given adequate back up for the blood problems I have and if so, how long should I take them once I get pg? Should I also be taking Steroids?

I hope you don't mind the abundance of questions but having gone through so many tests etc. I really want to be sure I am doing the right thing this time to first of all to get a BFP and that I don't m/c again.

Many, many thanks in advance for your thoughts!


B. Jacobs, M. D. - August 28

There are still too many unknowns. Many of the regimens that are being proposed have little or no scientific basis, but people try them anyway - I suppose out of desparation. One variable you may need to consider is not the stimulation protocol, but embryo transfer technique. Many of us belief it may be the most important part of IVF.
Good luck.


allison k - August 28

hello again Dr Jacobs

Thank you for your prompt reply.

I wondered if you could elaborate slightly on how the embryo transfer technique could be altered, as I'm not sure what the differences are.

With blast transfers I had ultrasound guidance (didn't get pg) and with all the others (FET and fresh) just normal transfer without extra guidance. Is there another way that I could talk to my clinic about?

I understand that the way the embryos are put back is very important in the outcome and that many clinics, who have poor statistics, are not advanced in this part of the process but my clinic (AZ UVB in Brussels) has stats well above the European average.

I would be most grateful if you could help me understand the different transfer techniques and which in your opinion is the best.

Many thanks


B. Jacobs, M. D. - August 29

Since I have not observed transefer techniques at the clinic you use, I cannot comment further. Even the way the catheters are handled and passed seem to make a difference.
Good luck.



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