Dear Dr Smith
I am hoping you can offer some advice. We have done three cycles of ISCI in a year and they have all failed we can only afford to do one last go and must give the last one the best possible chanc
I will give you our treatment history and I hopefully you can advise our next best option.
Iam 38 in nov and hubby is 33. Our problem is male factor.
I have also had inhibin B test done june this year result: 28.6 pg/mL.
March 05 FSH 5.6 LH 3.8
June 06 FSH 6.3 LH 3.7
Naturally i have a luteal phase defect 28-30 day period but when do ovulate is on day 17,18 or 19
on all cycles sniffed synarel once in each nostril am & pm.
All cycles have been at same clinic.
I have always had to carry on a few more days with stimming till follicles ok for e/c.
startened sniffing synarel16th aug 05. bleed came 10 days after started sniffing.
Day o scan 13th sept
started injecting 225iu Gonal F 14th sept & still sniffed till HCG injected.
Day 10 scan 23rd sept
Day 13 scan 26th sept - 17 follicles
HCG injection Pregnyl 5000i.u x2
Egg collection 27th sept - 12 eggs
Embryo transfer 30th sept - 5 had fertilised x2 grade 2 4 cell transferred.
Luteal support - Crinone Gel am & pm
RESULT - Had bleed on day 9 tested Negative 14th Oct
Started sniffing synarel 21st feb 06 - blled came on day 12
Day o scan 7th march 06
Started injecting 8th march 3 amps menopur & continue to sniff till HCG
Day 10 scan 17th march
Day 14 scan 21st march - 7 follicles
HCG Pregnyl 5000i.u x2
Egg collection 23rd sept - 5 eggs
Embryo transfer - all 5 fertilised (x1 grade 2 4cell, x1 grade 2 3cell, x2 grade 3 & x1 abnormal.
Transfered grade 1 & 2.
Luteal support - Cyclogest 400mg am & pm, Duphastom 10mg am & pm
RESULT - test date 8th april had bleed 2 hours after tested. brown discharge had stated on day 13 of 2ww
Prior to cycle started to take 75mg baby aispirin 1st aug
DHEA started 25mg 3 times per day from1st June
Started sniffing synarel 18th aug 06 didnt get bleed till day 16 of sniffing
Day 0 scan 12th Sept
Start injecting 5 amps menopur 13th spet & sniffed till HCG
Day 10 scan 22nd sept - 6 follicle right none on left
Day 13 scan 25th sept - 6 follicle right & 4 on left (10mm - 23mm)
HCG Pregnyl 5000iu x2
Egg collection 27th sept 8 eggs - x3 good, x4 immature, x1 shell only
Embryo transfer 29th sept - 3 fertilised x1 grade 9 out of 10 4 cell, x1 grade 8 out of 10 4 cell, x1 not good only 2 cell no nuclei.
Luteal support - Cyclogest & duphaston 3 times per day
RESULT tested 13th oct Negative and brown discharge had started.
I so hope you can help. Especially as that has just taken me ages to type all in.
I so look forward to your reply.
Thankyou very much
Mr & Mrs Booth