Hi Dr. Smith, would you mind commenting?
1 Replies
hoping4another - May 5

Extending fertility
New research suggests eggs can be grown in the lab from women's own stem cells, allowing some to delay motherhood by as much as a decade.

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By Ian Sample

May 5, 2005 | Scientists have used stem cells to grow healthy human eggs for the first time, a development they believe will usher in new fertility treatments and enable women to delay menopause by a decade. A shortage of donors means fertility clinics desperately need new sources of eggs to help women trying for babies through in vitro fertilization. The research suggests that a nearly limitless supply of eggs could be produced by taking a woman's own stem cells and growing them into eggs in the lab.

Professor Antonin Bukovsky, a researcher at the University of Tennessee in Knoxville, who led the work, says the findings show that women are capable of producing new eggs later in life, rather than being limited to the quota they are born with. At birth, a female's ovaries typically contain around 2 million egg-producing follicles, falling to around 400 by the time she reaches puberty. The number continues to fall until menopause, when too few exist for her to become pregnant.

According to Bukovsky, his work could lead to advances in fertility treatment that would allow women to grow and store their own viable eggs, and delay having a family until an older age. The stem cells could also be used to rejuvenate aging ovaries, with the potential of delaying menopause for 10 to 12 years.

In the study, which appears in the journal Reproductive Biology and Endocrinology, Bukovsky's team collected cells from the surface of ovaries in five women ages 39 to 52. They then tried different strategies to grow the cells in dishes over five to six days. The researchers found that cells grown in the presence of the growth-stimulating hormone estrogen transformed into large egglike cells, which later became mature human eggs capable of being fertilized.

Robert Winston, a fertility expert based at Hammersmith Hospital in London, said the achievement is highly important, if it has been proved to work: "If they've really done this, it would be extraordinary. There is such a shortage of eggs, it's incredibly important." Significantly, harvesting eggs from the outer surface of ovaries is a straightforward procedure, and can be done using a common flexible instrument called a laparoscope.

The use of stem cells to prolong the life of ovaries and so delay menopause is also a significant advance, Winston added. "There'll be a demand for it, particularly from professional women who want to pursue their careers," he said.

Bukovsky's team is now planning to test whether the stem cells they collected from women's ovaries can withstand being frozen. "Once we've frozen them, we'll thaw them out and see if they still work. If we can preserve them effectively, women could have them stored for 20 years," he said. If the next experiments are a success, thawed stem cells taken from a woman's own ovaries could be transformed into fresh eggs in the lab whenever they were needed. "This could extend fertility to the age of 60," Bukovsky said. Because the eggs are created just before use, they are less likely to be damaged or worn, as typically happens to eggs that remain in a woman's ovaries for long periods of time.

Scientists also revealed Wednesday that they have uncovered a new clue to the mystery of implantation -- the process by which an embryo becomes wedded to the womb. Implantation is the last step in the chain of events between fertilization and pregnancy, and one of the least understood. If an embryo does not properly attach itself to the wall of the womb, it cannot develop into a viable fetus. Scientists reported in the journal Nature Wednesday that they had identified a certain type of protein that appears to play a crucial role in implantation. The discovery may lead to treatments for some of the 20 percent of infertility cases that currently go unexplained.



Dr Smith - May 6

Dr Bukovsky's work appears promising, but not ready for prime-time just yet. They have yet to show normal embryonic development and differentiation to the blastcyst stage and, more importantly, the term delivery of a healthy baby from their ovarian stem cells. They have a ways to go yet. In addition, cryopreservation of eggs (and the subsequent development of viable embryos and term pregnancies) is still a hit-and-miss proposition. I expect to hear more from Dr. Bukovsky at the annual meeting of the American Society for Reproductive Medicine in October where he will be presenting his updated work.

The discovery that lysophosphatidic acid (LPA-3) is involved in implantation is interesting, but is only one of many, many specific molecules involved in the process. The discovery is welcome because we know so little about the activities of these molecules and the factors involved in the implantation process. I hope the authors will continue their work so that we may someday be able to accurately diagnose and treat specific "implantation problems".



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