embryology question
3 Replies
paddy - April 6

Hello again,

My embryo was transferred a few hours after day 6 1/2. The picture was taken at day 6 1/2 shows the embryo to be hatching and coming out of the zona pellucida (??) (1/8th of the circumfrances still attached).
It was so thrilling and I was amazed :D
The embryo part looks like mass of fluid with some sort of thick line (like a board) running across from the actual baby to the other side of the embryo part. What is this line called? Is this the stem cell. Does the baby then come out of the embryo shell and what happens to the zona, the embryo shell and the stem cell.

Is this a normal rate of embryo development and what is the success rates when transferred at this stage. I have heard chances of having a clinical pregnancy is higher at this stage.

thank you some much for taking time and answering my questions.



Dr Smith - April 7

A picture of a blastocyst stage embryo can be found at the bottom of this page: http://www.sharedjourney.com

thin, outermost ring is the protein coat (zona pellucida). The next ring inside is the trophectoderm cells that will form the sac that the fetus will grow in. The thickening between 9 and 12 o'clock are stem cells which will give rise to the fetus. After expanding to a point of rupturing the protein coat (hatching), the embryo then works its way out of the protein coat. The protein coat is left behind and eventually disintegrates. The trophectoderm of the free-floating blastocyst stage embryo then attaches to the cells that form the uterine lining. Once firmly attached, the trophectoderm cells begin to burrow into the uterine lining in search of a blood supply.

It is normal for an embryo to be at the hatching blastocyst stage on Day 6. The implantation rate for blastocyst stage embryos is approximately double that of Day 3 embryos. EACH blastocyst stage embryo transferred has approximately a 30% chance of resulting in a term pregnancy.


Karen Dennis - April 8

I have a question concerning an abnormal sperm morphology of 60 with limits being >75%. Below this it states predominant abnormal sperm Morphology: Cytoplasmic Extrusion. Other abnormal values were semen volume 6. Motility was 100 with 10% moving with no forward progression, 20% slow meandering movement, 30%rapid in an almost straight line, and 40% with a high speed in a straight line. Comment were WBC and clumping seen.
My husband is 53 yo. He has never had a child even though he did not try to prevent pregnancy. What are the chances of him conceiving a child?
I certainly appreciate your help. Karen Dennis


Dr Smith - April 8

Your husband's semen analysis was not performed by a trained Andrologist. This is apparent from the criteria used for sperm morphology and the nice round numbers for all the semen parameters. Accordingly, I'm not sure how much I can trust these numbers and I am reluctant to draw any conclusions from this kind of slap-dash analysis. The observations of white blood cells (WBC) and clumping are suggestive of antisperm antibodies. I would recommend having a semen analysis performed by a trained Andrologist at an infertility clinic and having the results interpreted by a Reproductive Endocrinologist. If this semen analysis was performed at an infertility clinic, go somewhere else for care immediately. If an infertility clinic cannot perform a modern semen analysis, chances are, they won't be able to do much else properly either.



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