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Topic: good eggs but slow embryos? (Read 11247 times) |
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anitasto
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I'm a llama!
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Re:good eggs but slow embryos?
« Reply #60 on: 08/16/06, 05:23 » |
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Hi Dr. Smith,
I completely appreciate your caution on the dhea case study. I've been researching this stuff like a hound as I am 39 and heading towards a 4th IVF cycle with diminishing funds.
Dr. Gleicher has discussed the larger study clinical results on June 17 ESHRE in Prague (link: http://humrep.oxfordjournals.org/cgi/reprint/21/suppl_1/i68.pdf ) and has 2 papers in press, one with FertSteril, the other with Human Reproduction. It seems like most docs aren't familiar with the updates Gleicher posts on his website or other related studies in addition to the 2000 IVF study and the 2005 case study publication (one Italian study that showed perimenopausal hormone levels returned to normal reproductive levels in all 30 subjects after 6 mos on dhea, plus another with 1400 women that directly related the 10% lowest DHEA levels to the same 10% lowest sexual function levels.)
Are you familiar with these studies and Dr. Gleichers latest?....are they relevant...
Do you think its reasonable that we poor responders move forward based on the info to date?
I had one consult where the doc said he wouldn't even offer a cycle with my own eggs and said he didn't think dhea would make any bit of difference. This was the #1 results guy in the US. So I faxed the most info I could find including the case study and, though it was new info to him, opinion unchanged.
Please help me understand the skepticism because I'm just a wanna be Mom.
Thanks so much for your time and input.
Anitasto
PS - And btw - I'm not an advertiser by any stretch.
Quote from: Dr Smith on 07/21/06, 08:07
The findings of this paper must be interpreted with extreme caution. It is based on a single individual (that's what a case study is). It was published in 2005 and, as far as I know, there has been no peer-reviewed, published follow up or confirmation by other investigators. I believe Dr. Gleicher is conducting a larger scale study based on his preliminary findings, but he has not yet published his findings in a reputable journal. Until his study is complete and published or his findings are confirmed by independent investigators, it should be interpreted for what it is. One woman had better eggs on a subsequent cycle. Happens all the time.
A cynical interpretation of linking this publication on CHR's promotional website is that it could be just a ploy to lure new patients. Every woman wants better quality eggs. What could be more enticing than that? It could be the ultimate sales pitch. Cave Canem - Buyer Beware
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Dr Smith
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Re:good eggs but slow embryos?
« Reply #61 on: 08/16/06, 08:53 » |
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Had to smile at your description of the morula. Yes, indeed, that's what it looks like. The cells get pretty small at the 12-16 cell stage (morula) and look about the same size as fragments in earlier stage embryos. Because it is contained within the zone pellucida, the embryo per se does not increase in size until it reaches the blastocyst stage. Prior to the blastocyst stage, every time the embryonic cells divide, the resulting cells are half the size of the original cell. So, they get pretty small at the morula stage and it looks like a "rasberry".
The "dark matter" could have been shading in the phograph or a few small fragments that have been pushed off to the side. Doesn't sound serious. It seems the embryo "caught up" and was at the appropriate stage for Day 4.
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dees
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Re:good eggs but slow embryos?
« Reply #62 on: 02/26/08, 22:02 » |
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Hi Doctor,
I am a huge fan of your honest responses, so I felt compelled to write to you.
A concise history of my case - 1 ivf attempt last september. 7 eggs retieved, none fertilised due to sperm not binding to egg. Just completed an ICSI cycle. Another 7 eggs retrieved, 5 fertilised. Day 2 - most at 3 cells, 2 are 2 cells,some with fragments. Day 3 - two are "A" grade at 6 cell and 7 cell. Three are "B" grade, one has 6 cells,and 2 have 4 cells. Day four - one is an early morula, and one is 8 cell. The rest are at day three stage. Day five (transfer day) - none have made it to blastocyst. They transfer one at 10 cell. The rest are too fragmented to use or freeze. (The plan was to transfer two blastocysts)
What do you make of my case ? Do you think the embryo quality is due to male factor ? Do you think that they did the transfer so they can say they did one ?
As I am not feeling confident about it, i wonder if you think it has any chance of success. Finally, any recommendations for future success ?
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Inna
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Re:good eggs but slow embryos?
« Reply #63 on: 03/03/08, 12:33 » |
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Dees,
Dr Smith is no longer available to answer.
Good luck to you!!!!
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IVF#1 Sept27
Beta 742 Oct27;3410 Nov1;
Kristian born July 12/07
He is now 7 mo, 20lb, 29"
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