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WantsBaby2
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To Fortyfour
« on: 03/22/05, 09:37 »
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Hi Fortyfour,
I remember on a post awhile back you mentioned that you never had a child with your first husband because he was lacking some enzyme in his sperm that kept it from pentrating and fertilizing your eggs.  I was just wondering how they determined that?

Our doctor has said that some of my dh's sperm has misshapen heads, and MIGHT be lacking a layer of something in the head that keeps it from penetrating.  Ever since you posted that info, I have had it in the back of my mind.  I hate it when I do that because this intuition thing of mine is almost right on target everytime.  I am afraid that this is what my dh has.

How rare is this condition?  How did they find out that he had it?  I hope you don't mind all the questions! 

Thanks Fortyfour!  I am sorry that you are so sick and I hope you feel better soon.  You are probably sick from all the stress your body has been through in the last month or two.  That would do about anyone in!

                                Wantsbaby2
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38 yrs.  DH is 31 yrs.  Married November 2002. No children. TTC since the honeymoon. Infertility treatments 2 yrs. 7 failed IUIs. 3 cancelled IVFs due to poor response to meds. Poor ovarian reserve.  DH has male factors. Chicago, IL  Presently looking into adoption!
Fortyfour
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Re:To Fortyfour
« Reply #1 on: 03/22/05, 12:30 »
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Wantsbaby2. - after 10 years of no baby they finally did a Hamster egg test on first hubby.    He had  misshapen heads, missing tails and low motility and morphology.  The hamster egg is close to a human egg so they see if the sperm can fertilize them.  They couldnt.    They did a wash (i dont know what)  to help the sperm to fertilize my eggs but it didnt help.      They said it was the enzyme that helps the sperm penetrate the egg that was missing.    Good luck,  I hear they are doing good things with this like ICSi.

Yeah,  I saw that sick kid on the day I felt the worst on hormones and should have called in sick.  Immune system low and here the bugs come.  I dont usually catch stuff from my patients anymore so I was not happy.    Take care girl.
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Forty Four years old, hubby is 52  married 4 years,  TTC 4 years with this hubby,  14 years with first hubby,  One adopted daughter,  2nd ivf done,  1st one pg with m/c,  second no pg.  Uses egg Donor.  PG with twins on 3rd IVF mc twins on 8/25/05
WantsBaby2
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« Reply #2 on: 03/22/05, 12:53 »
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Fortyfour,
Yep, my dh has all of those things, misshapen heads, some with no tails.  His motility is ok.... but not great.  Morphology is at about 35%, not that great either.

Do you know if they still do that hamster egg test?  Do you know what it is called?  I would rather them do this test first than find out at the time of IVF transfer when I have put my body through so much already and wasted a retrieval.  If my eggs don't fertilize, I hear that emergency ICSI doesn't work so well usually.  So much to worry about eh?  Thanks for your response.  I just have a feeling ya know?

                          Wantsbaby2
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38 yrs.  DH is 31 yrs.  Married November 2002. No children. TTC since the honeymoon. Infertility treatments 2 yrs. 7 failed IUIs. 3 cancelled IVFs due to poor response to meds. Poor ovarian reserve.  DH has male factors. Chicago, IL  Presently looking into adoption!
Meg
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« Reply #3 on: 03/23/05, 01:04 »
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WantsBaby2,

When we were going through our IVF's and sperm testing, I posted all of my questions to Dr. Smith.  He is very informative on sperm issues and always gave me great answers to my questions. 

I also researched sperm and the male reproductive tract until I thought I could teach a course on sperm.  We even went and saw a urologist hoping to help his problems, but unfortunately he wasn't a infertility urologist, so my husband's issues were never really resolved.  His main problem is that he has poor morphology - 3% to 8% range, all were close to 3 except one time it was 8.  He also had a very bad prostate infection for over a year that he didn't know about.  This was indicated by high White Blood Cells present w/ the sperm.  The prostate infection may have caused my husband's sperm to develop antibodies to themselves, which has no cure, so they all stick together.  When we visit the RE again, I may ask for him to get an antisperm antibody test, when he gets retested.  His motility has ranged from fair to borderline good. 

Our main concern though is the morphology.  When the sperm are deformed, they have bad DNA.  Generally when the sperm are deformed they can't fertilize and egg. It is nature's way of preventing a m/c or an embryo with bad DNA.  I often wonder if it my DH sperm are responsible for the miscarriages as they seem to be chromosomal issues.  I asked the Dr. if it is possible for a "bad" sperm to fertilize, and he said it can be possible but usually they won't be able to fertilize.  I always go with anything is possible. With ICSI they try to pick the best sperm and fertilize the eggs.  I always worried that they may pick a sperm that looks "normal" but may not be.  We did have 22 of our eggs ICSI'd and the clinic took 8 eggs to see if any fertilized naturally and 4 did fertilize naturally.  I think they only picked 8 b/c they didn't want to take the chance that some wouldn't fertilize.  I feel like doing IVF is like buying a car sometimes, b/c there are so many options that you can go with - would you like ICSI with it, or how about Assisted Hatching, or even PGD??  Of course all of these options will cost you anywhere from $1000 to $10,000 extra Isn't infertility so much fun??  Could you just say you want ICSI from the beginning so as not to have to worry about rescue ICSI or about eggs not fertilizing?
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DH and I are 36. Married 9 yrs.  p/g  4/01 m/c @ 9 wks.  DH dx w/ severe mf - told best chance of conception was IVF.  1st IVF 5/02, m/c @ 7 wks. FET 5/03 conceived triplets and lost triplet at 11 wks. gestation.  Had B/G twins @ 32wks.  ++ p/g 5/5/05 conceived nat. much to our surprise
WantsBaby2
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Re:To Fortyfour
« Reply #4 on: 03/23/05, 08:10 »
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Thanks for your response Meg.  I really appreciate it.  Maybe we need to see a urologist that specializes in infertility.  It is probably a good idea to get him checked out since we have problems with count, morphology and motility.  (Yeah, we get the triple whammy)  I'm sure we could find one in the Chicago area.  I am sorry you and your dh have had so much trouble.  What a pain this whole business is!

I suppose we could ask for ICSI from the beginning.  I would just hate to ask for it and not need it.  I have heard that ICSI takes away the element of natural selection...so that worries me a bit.  I have to research things and I sure appreciate your advice.

                            Wantsbaby2
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38 yrs.  DH is 31 yrs.  Married November 2002. No children. TTC since the honeymoon. Infertility treatments 2 yrs. 7 failed IUIs. 3 cancelled IVFs due to poor response to meds. Poor ovarian reserve.  DH has male factors. Chicago, IL  Presently looking into adoption!
Fortyfour
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Re:To Fortyfour
« Reply #5 on: 03/24/05, 14:37 »
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Wantsbaby2,  Sorry I was offline yesterday, my daughter was monopolizing the computer.  The test was simply called the Hamster egg test in the literature at the time.  This was 14 years ago.  If it has a new name I do not know.  Good luck with this.  It so damn frustrating that we have to do so much leg work to get pg.  Keep in touch with this process?.

Hey you guys what is assisted hatching?




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Forty Four years old, hubby is 52  married 4 years,  TTC 4 years with this hubby,  14 years with first hubby,  One adopted daughter,  2nd ivf done,  1st one pg with m/c,  second no pg.  Uses egg Donor.  PG with twins on 3rd IVF mc twins on 8/25/05
meridithhasfaith
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« Reply #6 on: 03/24/05, 15:01 »
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Hi 44

Assisted Hatching is when they actually assist the egg in breaking out of that tough outer membrane to encourage implantation. They just literally make a small hole in the outer membrane of the embryo and transfer proceeds as normal. I had it done when I had ICSI done in 1997 and I didn't even know it until I reviewed my records before forwarding them to the new RE. It's amazing what they can do.
Hope you are feeling better soon! (I always get my period when I am sick with something else, it's a conspiracy!) 
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36 years old. Married for 17 years. 1 son, 7 years old, conceived w/ ICSI. 2nd IVF w/ ICSI in June=No Fertilization. August cycle cancelled for poor response. Considering options.
Fortyfour
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Re:To Fortyfour
« Reply #7 on: 03/24/05, 15:23 »
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Thanks for the info.  Wow  it is amazing what they can do for us.    Take care
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Forty Four years old, hubby is 52  married 4 years,  TTC 4 years with this hubby,  14 years with first hubby,  One adopted daughter,  2nd ivf done,  1st one pg with m/c,  second no pg.  Uses egg Donor.  PG with twins on 3rd IVF mc twins on 8/25/05
cassandra
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« Reply #8 on: 03/24/05, 21:07 »
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Hi fortyfour! Sorry to hear you were so sick! Did you get antibiotics? Have things been going ok this week besides?How was hollywood? I've never been to CA but after this winter here, I'm ready to live there!I almost cried last night cleaning the snow off my car after work. I HAVE HAD IT WITH THIS WEATHER!I hope everything is well with you.How is the job search going? Are you trying for less commute time? Just thinking of you. Take care......cassandra
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33 yrs old married to dh 12 1/2 yrs. scarred fallopian tubes from laser surgery for cervical cancer cells 3rd ivf attempt in march, now pg. with b/g twins due 12/15/05
WantsBaby2
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Re:To Fortyfour
« Reply #9 on: 03/25/05, 02:48 »
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Thanks Fortyfour,
I will do a little research on that.  Maybe I am just borrowing trouble as my mother always tells me I do!  Here I sit in the middle of the night not being able to sleep!  It seems to never end! 

I am sorry you are sick, but glad you are feeling a little better?  I hope.  Any decisions yet about the new donor?

                              Wantsbaby2 
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38 yrs.  DH is 31 yrs.  Married November 2002. No children. TTC since the honeymoon. Infertility treatments 2 yrs. 7 failed IUIs. 3 cancelled IVFs due to poor response to meds. Poor ovarian reserve.  DH has male factors. Chicago, IL  Presently looking into adoption!
cassandra
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« Reply #10 on: 03/25/05, 13:02 »
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To Fortyfour, I've been trying to look for your post asking about assisted hatching.Was it you that asked about it? I was looking in my handbook this morning and thought of you.It says as follows: Assisted Hatching improves pregnancy rates for women over 40 years old, but it is not helpful for younger women. Assisted Hatching involves making a small hole in the outer covering of the embryo(the zona pellucida), making it easier for the embryo to hatch and hopefully implant. It is performed on the morning of embryo transfer.    cassandra
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33 yrs old married to dh 12 1/2 yrs. scarred fallopian tubes from laser surgery for cervical cancer cells 3rd ivf attempt in march, now pg. with b/g twins due 12/15/05
Fortyfour
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« Reply #11 on: 03/25/05, 17:56 »
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Thank you everyone for your information and well wishes.      When I woke up today I finally knew I was feeling better.    Terrible bug this one was.

I got called by my new employeer and it looks like I have a new job.  Yeah!.    I will be driving a whole lot less and nowhere near LA.    I will also be getting a $5 an hour raise from the last job.  I decided to take the benefit package and need to look and see if IVF is covered at all.    It will be 3 days a week which is perfect in case I want to work at the hospital a day for extra money.

My daughter is going home today  :'(.  It  is so hard to have her gone so far away.  The only positive is she is finally getting to know her dad. 

Take care everyone.

I am still pondering the donor issue.  Who to ask. how much to pay.  when to do it.  Crazy.
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Forty Four years old, hubby is 52  married 4 years,  TTC 4 years with this hubby,  14 years with first hubby,  One adopted daughter,  2nd ivf done,  1st one pg with m/c,  second no pg.  Uses egg Donor.  PG with twins on 3rd IVF mc twins on 8/25/05
cassandra
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Re:To Fortyfour
« Reply #12 on: 03/26/05, 08:44 »
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Fortyfour, I'm glad your'e feeling better. Congrats on the new job and commute!I wish I could donate for you. I hope the new job has those bennies for ivf. How exactly do you go about finding a donor? Does the dr do it? Do you have to pay for her meds? I'm just curious.  cassandra
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33 yrs old married to dh 12 1/2 yrs. scarred fallopian tubes from laser surgery for cervical cancer cells 3rd ivf attempt in march, now pg. with b/g twins due 12/15/05
oneandonlymel
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Re:To Fortyfour
« Reply #13 on: 03/27/05, 06:42 »
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Fortyfour, glad to hear you are back on your feet and congradulations on your new job and raise! I wish the best for you on whatever you decide to do!
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35 yrs old, dh is 38,married for 5 years on May 20th. have been ttc for 3 years, 3 miscarriages diagnosed with homo MTHFR and factor II mutation, trying on our own, did have one IUI but failed. BFP 7-21 05
meridithhasfaith
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Re:To Fortyfour
« Reply #14 on: 03/27/05, 11:27 »
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Hi Fortyfour

That stinks about your daughter having to leave.  Time just flies, doesn't it?
Congratulations on that job! What a great position! More money, fewer hours and less of a commute. Can't ask for much more than that! I saw someone say something about a "rider for IVF" that you can add to your current medical insurance if you aren't fortunate enough to be living in one of the states that mandates infertility treatment be covered. Just thought I would mention it in case you weren't aware of that.
Good luck checking everything out!

Meridith
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36 years old. Married for 17 years. 1 son, 7 years old, conceived w/ ICSI. 2nd IVF w/ ICSI in June=No Fertilization. August cycle cancelled for poor response. Considering options.
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