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Topic: ICSI - no egg fertilized (Read 1077 times) |
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B. Jacobs, M. D.
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Re:ICSI - no egg fertilized
« Reply #15 on: 04/17/08, 17:12 » |
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There are several variants of several protocols. There are several different products available which contain the FSH need to grow follicles. I do not know the product, Suprecur by that name. I assume you are not in the United States. It is probably 1 of several which prevents the release of FSH and LH from the pituitaty.
Good luck.
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sublue
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Re:ICSI - no egg fertilized
« Reply #16 on: 04/17/08, 17:26 » |
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Thank you. Suprecur is the down regulator.You are right I am from UK. Many thanks for your reponse. Is there any particular protocol/drugs you recommend? My clinic suggest i go for egg donation but i dont think i am ready for that. I have asked for all my notes so i can get a second opinion but havent got them yet.
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B. Jacobs, M. D.
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Re:ICSI - no egg fertilized
« Reply #17 on: 04/17/08, 22:25 » |
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It would not be appropriate for me to make medical recommendation to someone who is not my patient. I do not knowthe clinic you are using. The only one I know, first hand, in the UK is the Borne Hall Clinic, and its medical director Mr. Peter Brinsen. If you would like a second opinion, you might see him.
Good luck.
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TheMuzys
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Re:ICSI - no egg fertilized
« Reply #18 on: 04/25/08, 05:32 » |
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Dear Doctor,
I am 32 and my husband is 37 and we have just had our 1st cycle of ICSI. I responded well to the drugs and produced 12 eggs of which 9 were mature enough, 3 were said to be immature and by English law could not be injected. Of the 9 mature ones, 3 fertilised abnormally and 6 did not fertilise at all. Obviously we are both devastated. We cannot understand how this could have happened. I have blocked fallopian tubes but are otherwise fine and my husband has 98% abnormal forms (morphology). His count this time was about average and he has a 6 year old daughter from a previous relationship. I have conceived twice before at a very young age (16 years ago). We dont know what to think, we trust our clinic and what they have said but we cannot help but think that human error could have played a part in this. The clinic had a power cut before we arrived and was running from generated power. Saying that we have been told ICSI was performed on other couples the same day and was successful. We have decided that we will have another attempt but we wondered what tests could be done on my husbands sperm? The consultant said that it could the eggs or it could be the sperm. Is there some sort of DNA test he could have before we set ourselves up for more heartache? They also mentioned something about the sperm breaking down??
Is this what you refer to as decondensaton?
Any advice would be greatly appreciated.
Many thanks,
Steve and Melanie
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B. Jacobs, M. D.
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Re:ICSI - no egg fertilized
« Reply #19 on: 04/25/08, 06:26 » |
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There are actually several products on the market that contain FSH. I prefer the FSH-only products. For pituitary supression, I use Lupron for either down regulation of the pituitary or for the flare effect in those patients who are poor responders.
Good luck.
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jjauth
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Re:ICSI - no egg fertilized
« Reply #20 on: 04/28/08, 18:22 » |
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I am a just-turned 37 single woman with good FSH (4.6 this cycle) and a history of responding well to fertility meds. After 6 failed IUIs, I am now doing my first IVF cycle. I had 20 antral follicles on cd2, and responded well to low dose of stims. I had 16 eggs retrieved on Friday, 14 of which were mature. The next day, I found out that only 5 eggs had fertilized. Of those five, four are 4-5 cells on day 3, and only one has made it to 8 cells (and it is "good to fair" quality). I'm waiting to see if it (or any of the 4-5 celled embryos) make it to day 6 for transfer.
My questions have to do with the low fertilization rate and "poor" embryo quality of those that did fertilize...and what this says about my egg quality.
ICSI was not used because the donor sperm I used was reportedly fine. The doctor said that sperm was not binding to my eggs, and that this may be a problem with receptors on my eggs, which can be taken care of by ICSI.
I am terrified that all of this suggests that my eggs are not good. This is confusing to me, since all of my numbers have been fine up until this fertilization report. Any thoughts or help is greatly appreciated.
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B. Jacobs, M. D.
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Re:ICSI - no egg fertilized
« Reply #21 on: 04/29/08, 06:34 » |
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I do not know Supercur, or the dose you used. I assume it is similar to Lupron, which can suppress ovarian response. I do not use a product containig LH, as Menopur does. I use products that azre only FSH.
Good luck.
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