I have the mutation and didn't find out about it until now in my third pregnancy. Both of my other two children were born premature sectioned because of pre-eclampsia and both were with gestaional diabetes. I am now 32 weeks 2 shots of heparin a day and 1 81 mg baby asprin.
I apparently have been very blessed to have not lost a child as alot of you have. I am so sorry to all of you for that. I guess because I have not had that happen yet to me my specialist did not feel it was important to go into all of that.
Good luck to you all and I wish you happy healthy babies.
Just out of curiosity, how many of you on this board had a normal first pregnancy then followed with all these problems? I had a perfect first preg followed by 5 miscarriages. I too have MTHFR c677t and the last one was treated with lots of vitamins and the famous lovenox injections but it still did not work for me. I think my doc wants to try prednisone, a steroid, next because it suppresses your immune system--they think my body may be attacking the baby. I am so lost as to what do next time. Still lots of testing to be done! uurrgghh! Any input would be great. THANKS
I'm posting an update. I am at 25 weeks, my 24 week checkup was last week. Things are still going well. Baby's heartneat sounded great and growth is right where it should be. I continue to inject .75cc of heparin (10,000 usp) twice daily and take baby aspirin, prenatals, folic acid, b6 and b12. Baby is active in there. I will have another ultrasound at my 28 week appointment. I still harbor paranoid feeling, but still so far so good.
I have just found out have the gene mutation MTHFR hetero. My doctor suggested egg donation. I have been busy resarching and would like to know if anyone else has this mutation? What did you take during pregnancy? I have lost 4 pregnancys in the last 2 years. None have been longer than 8 weeks. I have been reading about folic acid, asprin, blood thinners, B vitamins......Are these suggested when you are hetero??? Please just wishful thinking.....hoping for suggestions to try one more time......
wishful thinking, I am so sorry for your losses. I too am hetero for MTHFR. I have lost 5 pregnancies. My lastest was at 20 weeks. It has been a struggle. I lost the last one a week ago at 12 weeks. I was on tons of vitamins ( high dose folic acid, B6, B12, prenatals, baby asprin, and I was taking 40 mg injections of lovenox per day- a form of heprin-a blood thinner.) Although it did not work for me I HAVE seen many reports of it working for others with the same condition. I think I have something else going on just don't know what it is yet. If I may ask, why is your doc suggesting an egg donor? I wish you the best! Heather K
My wife has delivered two healthy sons with this mutation. I believe she had many early miscarriages but we only had one confirmed at about eight weeks.
Her first pregnancy was in 1995. She developed a blood clot in her lung at about six weeks. She was diagnosed with antiphospholipid syndrome at the time. She administered 10,000 units of heparin daily until natural (induced) delivery. She discontinued blood thinners and developed deep vein blood clots within ten days. She began a regimen of coumadin for two years until her blood work without it came back normal for clotting.
She convinced me that knowledge on the subject had advanced enough so that another pregnancy should be considered. We miscarried as mentioned and became pregant again in late 1998. She again began heparin injections but developed deep vein bllod clots in her legs at eight weeks. My second soon was born five weeks premature with only slight difficulties. My wife is now on coumadin for the rest of her life. I had myself sterilized during that pregnancy because I didn't want to put her life in peril again.
Subsequently, my wife's aunt succumbed to pulmonary embolism and the mutation was discovered in her autopsy. My wife has since been tested and was also detected.
We have been fortunate. My wife's doctors learned a lot from her case and perservered with sketchy information. Medical problems without answers are only temporary to the extent that more is known each day. And in that light, I must say that my wife was pushing for answers every day she carried our children.
Allow me to offer my prayers and best wishes to everyone who struggles to overcome this condition.
Message to Heather K: I am one that has a 3 1/2 year old (this was my first pregnancy) that was completely normal - no problems at all. Then the two pregnancies after that have ended in miscarriage - one at 10 weeks and the other at 25 weeks. I am pregnant now - in week 23 and hoping to go to the end (at least to 38 weeks when my OB will induce).
To answer some of the other questions out there: My hematologist told me that after giving birth, she would only keep me on the folic acid and switch me from Lovenox to Cummin for 6 weeks and then take me off of everything. The MTHFR by itself is not a reason to be on medicine unless the homosystin levels are high. She did tell me to always keep an eye out for blood clots. It I were to get pregnant again, she would recommend the same items that I am currently taking once a day: regular prenatal vitamns, foltex (combo of extra folic acid, B6, B12), baby asprin, iron supplements, and lovenox.
AL, Thanks for responding to my question. I am so sorry you have gone through losing your babies. I know how hard and frustrating it is. I have lost one at 20, 16, 12, 10, and 8 weeks-not in that order. I just really wonder why my 1st [preg] was okay and now I am having so may problems. I have noticed that a lot of others have one and then start having problems too. I wonder if there is something to this. Maybe I just take notice more to people who are in the same situation. I am getting so frustrated and want another child for my son to grow up with. He just keeps getting older!!! Best of luck to you with your pregnancy. I hope the protocol your doctor is giving works miracles for you!!!!
Hello, I'm new to this forum. I've had 3 miscarriages before they told me I had MTHFR (both genes). I take 2 b6, 2folic acid, 1b12, and 1prenatel 2xs a day. I was very happy to see that my doctor cared enough to help me. Being an Army Wife, some doctors just say what they want and thats it. So far so good. I do have a question, reading some of the posts, I've noticed that some of you are taking shots??? What do the shots do for you? I have a check up coming up and I was just wondering about them is all. Any adivise on the shots would be greatly appreciated. Thank you.
Heather K.-- I also had 3 healthy full term babies with no complications THEN went on to have 2 tragic losses in the past year! That baffles me also. I lost my son Ethan at 18wks in Aug. 2005 and just lost little Emma at 20wks in March. OB did 8different clotting tests and determed I have MTHFR mutation. I am now on folic acid, B6, B12, and 81mg aspirin. It is VERY hard to understand why my 1st 3 were fine, but last 2 were not. My OB seems to think that everyone's risk factor is different which makes sense if you are looking at homocystein levels. We want to try again --but our losses were so tramatic to us that I am very nervous, but this site has been encouraging!
I am 34 years old I have 2 teens and had 8 miscarrages I went Through IVF I now have 8 year old triplets with learning disabilities and autisum Aspergers. I have had 3 strokes in the last 7 months my doctor finaly did a gene test and I have Mthfr C677T on both alles. Yet before this all my test results were coming out negative so they did not know what was causing the strokes. now I am finding that this gene disorder can cause miscarrages strokes and learning disabilities in your offspring. a good website to go to is www.metanx.com [ quote author=A & L link=board=4;threadid=471;start=45#15201 date=1140008541] I recently was tested for MTHFR along with many other tests. I have two copies of the C677T mutation which are homozygous. I was only tested for this after I lost my daughter at 26 weeks last year and had a previous miscarriage before that pregnancy. My first pregnancy in 2002 went fine with no problems. I am pregnant again and this time I am seeing my regular OB and a high risk pregnancy specialist and recently went to a hemotologist. I am currently taking my regular prenatal viatimn, extra folic acid, baby asprin (80 mg), 2 doses of iron and one shot of lovenox per day. I had a sonogram done at 7 weeks and will go for another one at 12 weeks and then I will have sonograms every 2 weeks until week 26 and then once a week from then until the end of the pregnancy to monitor the babies movement just in case there is a blood clot somewhere that they cannot see from the sonogram. They are thinking that there may have been a blood clot somewhere that caused my daughter to die. I am hoping that everything goes well this time. I also got a second opinion last week from another OB and he agreed that everything that I am taking is exactly what he would give me as his patient and would also monitor me thoughout the pregnancy with sonograms. I feel much better that everyone has told me the same thing.
I just found out today that I have the mthfr mutation. The Dr said i have 2 mutations, what does that mean? He said I got one from each parent. As this is genetic I think I would like to have my kids tested. Some of you will probably hate me for this.....I have 4 healthy kids 17,14,10,8. After the last one I had my tubes tied. Knew it was the wrong choice for me, both mentally and spiritually. I had a reversal last year (05). Got pregnant in Dec 05. Found out in Jan, then m/c a week later. I was diagnosed almost 6 yrs ago with Takayasu's Arteritis, so therefore my reg. obgyn sent me to a hi-risk ob when I got pg this time. Their office is where the blood work was done for the mthfr. I don't even know why it was done. They ran b/w today to check my homocystein levels. I think I'll call the office to find out exactly which mutation I have. Now I'm curious to know if it had anything to do with my earlier m/c? Bless ya'll for being geneous enough to post your most painful experiences and trying to help others through their difficult times! I know it's hard, but we have to keep the faith, that somehow it'll all work out for the best. Whatever that may be! Thank ya'll for being here and for listening to my rambling!
Unfortunatly I am not familiar with the mutation. I did however want to jump in and say hi in response to your post and welcome you. This site is a wealth of information. You name it you probably can find it, not to mention the wonderful loving caring women who are here. I have personally learned so very much and have made some great friends. Without them, I don't know where I would be. Maybe crazy.
You are very fortunate to have 4 beautiful children.
I wish you the best of luck in your journey, I hope you can find the answers you are looking for. Hopefully someone with some good experience can help.
Hi, never done this before, just got news that I am compound heterozygous for MTHFR C677T and A1298C- I delivered a healthly boy Feb. 06. Had blood work for a superficial clot in leg post c section. Curious to know if anyone had a sucessfull pregnancy again with just more folic acid and vitamin B and baby asprin? I do not know much about the injection... any info would be great
My name is Connie I have MTHFR duble copy. I found out after three loss. Does anyone now if Iwould have to take Heparin before of ater I find out I'm pregnant? My doctor said he does not think I will need to do the heparin . Right now I'm on Folgard and baby asprin We lost out baby girl at 13 weeks about six weeks ago. Help what should I be taking if I want to have a baby again?
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