I recently was tested for MTHFR along with many other tests. I have two copies of the C677T mutation which are homozygous. I was only tested for this after I lost my daughter at 26 weeks last year and had a previous miscarriage before that pregnancy. My first pregnancy in 2002 went fine with no problems. I am pregnant again and this time I am seeing my regular OB and a high risk pregnancy specialist and recently went to a hemotologist. I am currently taking my regular prenatal viatimn, extra folic acid, baby asprin (80 mg), 2 doses of iron and one shot of lovenox per day. I had a sonogram done at 7 weeks and will go for another one at 12 weeks and then I will have sonograms every 2 weeks until week 26 and then once a week from then until the end of the pregnancy to monitor the babies movement just in case there is a blood clot somewhere that they cannot see from the sonogram. They are thinking that there may have been a blood clot somewhere that caused my daughter to die. I am hoping that everything goes well this time. I also got a second opinion last week from another OB and he agreed that everything that I am taking is exactly what he would give me as his patient and would also monitor me thoughout the pregnancy with sonograms. I feel much better that everyone has told me the same thing.
I actually am pregnant 8 weeks through IVF for the first time. I have never been pregnant before. However, my fertility specialist stated that I tested positive for MTFHR and APA, as well as my homocystine levels were abnormal?? Therefore, I have been on Heparin 5000 injections twice daily since they confirmed the pregnancy on 1/23/06. I also am taking folgart 2.2 mg. twice daily and baby aspirin orally.
I have never been pregnant before, nor had any miscarriages. Can any one explain what MTFHR is? I am so confused?? No one in my family has a history of cardiovascular and/or vascular problems. And, I was told by my obgyn that once she studies the testing results I may have to continue the injections through the whole pregnancy and see a high risk specialist.
I have had 2 mc and recently lost my baby boy at 28 weeks. Testing for MTHFR revealed a single mutation. Can someone explain to me what this means? My dr. says this is not significant and you need to have 2 mutations for there to be a problem. Autopsy on my son revealed 2 small blood clots in the placenta that probably restiricted his oxygen supply.
Hi, My son and daughter-in-law have lost 2 babies since March of this year. They have a son who was born 4 years ago and they're wondering if they can ever have any more. My daugter-in-law just found out about this C677T mutation on Tuesday (11-1-05). The specialist seemed optimistic that they would get pregnant and be able to carry to term. The specialist also told them that because of this mutation, the placenta clotted over thereby causing the demise of the fetus.
I have 4 healthy babies. I found out that I have the C677T/MTHFR (HOMO) mutation just days before delivering my third child. They quickly tested my homocystine levels (which were in range)and based on my successful pregnancies we did not use a blood thinner. No special precations on my 4th pregnancy. My mother is (homo) MTHFR and had 6 successful pregnancies in her twenties. I have 5 brothers and sisters, right now we know that 3 of us are (homo) MTHFR and one is heter, two undiagnosed. One of my sisters who is (homo)MTHFR has had one successful pregnancy, one early miscarriage and is currently pregnant due in June. I hope that is gives hope to those who are trying.
Yes! I suspect that there is much more to research. I had 2 successful pregnancies--in 1970 & 1975--not knowing I was homozygous for c677t & husband is at least heterogous for A1298C. I recently learned this because of my daughter's 2 miscarriages & now successful pregnancy. Three months into her pregnancy, she was treated with Folgard & baby aspirin & am not certain how long she will continue this regimen. (Recent studies show controversy about this treatment in regards to cardio-vascular health--but don't seem to address people with this gene mutation.) My recent visit to hemotologist did not suggest major treatment--but stated that OB doctors did treat their patients. My own pregnancies were not complicated--didn't even take vitamins--such is life. Now I must follow knowledge in regards to my vascular health & my son's and hope for continuing research that will help young women. (My daughter is 35--first child--& of course, he is beautiful!)
Hello, i am about 3 weeks post miscarriage, this was my second. and i just found out that i am positive for mthfr gene mutation. I am homo for it which means i have 2 copies of the c677t mutation. But luckily that is all i have cause i do know that there are other things that i was tested for that are related to mthfr but i tested negitive for those which was some good news. And my doctor also said that my homocystine levels are normal, so i think that is a good thing also. I go and see a specialist next week to find out what to do next. I guess my biggist worry is will i ever beable to have a healthy baby? Or will i carry to full term..it is comfortating to know that i am not alone and there are other people out there with the same problem. I have read that i have a bigger chance of having a baby with a nural tube defect, or and spine bifida, it scares me to death, i would love to hear from anyone that has this gene mutation and has had healthy babies...i guess i just want some kind of hope. Best luck to all of you!! Kristin
I was recently tested and found to be positive for 677&1298, put on Metanx once per day for life. I was tested because I am ttc using IUI and m ysister is 7 months pregnant and she was found to have it so I got checked. She is on Metanx too and at 26 weeks- all is well for her and her baby boy! good luck
I recently had a baby boy. At the begining of my 3rd trimester I started to have contractions. Due to the contraction I started seeing a specialist and had ultrasounds to check for movement on a weekly basis. At 39 weeks he didn't pass the test, so that night they took my son by c-section. I now have a healthy baby boy but they found 3 blood clots on my placenta. Due to that I had my blood tested and found that I have C6777T mutation and am homozygous. What does that mean? I am now taking folic acid 1 mg and a baby aspirin on a daily bais. My question is does my family need to be tested for this. My sister has a 1 healthy child already but is thinking about having another child. Does she need to be tested for this?
I just got the test result that I have MTHFR mutation and it's homozigot. I felt myself highly depressed while I was searching what it would mean...we are ttc for about 2 years or more, had one miscarriage and nothing at all and we had never had any contraceptive...Now that I read all about your stories and comments I feel a bit relaxed by now but still looking for answers? since I am homozigot, does it mean I'm more challenged for having a healthy child, shall I give up, do heparin and these shots really work also for homozigot mutations...and does it mean pregnancy is more risky for more health, I'm almost 35...I always had the feeling that something was wrong but did not expect something serious like this... please help me, I don't know what to do....
Hi I am new to this forum. I want to say hello to everyone out there in cyber space! I do have good news for you. I had my first and only clot in summer 2002 at age 25 ( dr's never knew why), when I became pg with my son in '05 My ob knew to test for MTHFR among other things. Results returned + , for hetero MTHFR the C677t form, so at 2 months I started heparin injections twice daily ( b/c insurance would not cover lovanox) and was referred to a high-risk dr. She did an ulltrasound once monthly and I continued to see my regular ob too. I was on calcium, 1mg folic acid, 1mg iron, and a rx prenatal ( about 7 pills daily). My son was born healthy. I just learned I am pg with baby #2 so I am hopeful for a similar outcome. Take care!
My daughter is compound heterozygous for the MTHFR mutation. She had one early miscarriage and is now pregnant at 22 weeks. She just had a peri visit with ultrasound and reported the baby is doing great. My daughter started taking folic acid before ttc because I had an anencephalic baby. She continues the folic acid and is also on heparin and baby aspirin which she started before conceiving the second time.
We're thrilled that she is doing well so far and also concerned about the next few months.
My Name is Monica Im 26 years old, I have One 5year old daughter and almost 1 year ago on April 7th I had a still birth @ 36 weeks preg.Had to give natural birth to my daughter Serena. My 1st pregnancie was text book perfect then after my loss Dr's discovered that I have MTHFR mutation there were blood clots in the placenta..If there is anyone who has gone threw this and has continued with a sucessful pregnancy please help...
Well I know I have a factor II problem and at this point am not sure if I have the mutations or not, all I am really sure of is Factor II one copy..... I have 4 m/c in relation to this with no pregnancy really advancing beyond 12 wks or so ( a seasoned pro you might say). I became pregnant by accident in December (2005) and because of past results and the emotional stress of failure each time (graduating levels of treatment with ea. pregnancy) I decided to ignore the whole thing and let nature do what it would do (since that seemed to be what would happen no matter my efforts). In Feb 06 I thought myself to have had the inevitable ( in my mind) m/c and went on with life. I did as I've always done 4-6 weeks later (after m/c) and took a preg test to see if all was back to normal ( if you have retained some of the pregnancy material a test will likely still show positive). Well my test showed positive (meanwhile the decision to have a tubal ligation done and the process to adopt had all been started and made) so I called my OB so see what the next step was. That next step to me seemed a D&C to remove any remaining "stuff". So I went in and they began with a vaginal ultrasound and maybe 10 second in to that the tech says " Well you're too far along for that." and she switched to the external abdominal US. To the shock of everyone in the room familiar w/my history, I at that point was 17 weeks and 2 days along and progressing in a normal way. I immediately began pre-natals, extra folic acid and baby aspirin. When my regular doc returned from vacation he put me on profalactic heparin ( self adminstered twice a day) for the duration of the pregnancy. So far so good. Who is to say how we got here this time as I had fully given up hope ( and still have yet to invest full hope and excitement) in sucess. All I can say is become more informed, find a doctor who WILL work with you on this and keep trying if it is in you to do so. If this had not happened the way it has, I would be on my way to adoption, and repeated miscarriages are tough on anyone, but with the right phsyician you may be able to be spared that!!!! I hope in August that I can say "sucess"!!!
Has anyone ever heard of this causing something called "Limb-Body Wall Complex?" I had a baby in Dec. I was 28 weeks. He had this. Now they want to test me for all sorts of things, MTFHR being one of them.
BTW, if I do have this, it's so great to here success stories. I'm so afraid that there's something wrong with me, and that I'll never have kids again.
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