Hi, My son and daughter-in-law have lost 2 babies since March of this year. They have a son who was born 4 years ago and they're wondering if they can ever have any more. My daugter-in-law just found out about this C677T mutation on Tuesday (11-1-05). The specialist seemed optimistic that they would get pregnant and be able to carry to term. The specialist also told them that because of this mutation, the placenta clotted over thereby causing the demise of the fetus.
Hello. I am 34 years old and have suffered 3 miscarriages. My 1st miscarriage I was 27 and about 4 weeks along. I chalked it up to bad luck. My second pregnancy I was 29 and carried a healthy baby boy to full term and natural delivery. I thought if I wanted more children it would be no problem - based on that pregnancy being so text book normal. I got pregnant again at 33 and miscarried at 16 weeks - it was physically and emotionaly traumatic. My sister in law was also pregnant and about as far along as I was - so it was diffacult. Again I was told it was bad luck and to keep trying. We did and got pregnant again 4 months later. I miscarried again at 4 weeks. At that point I went to a fertility specialist who ran tests and informed me I had 2 copies of C677T. She put me on baby aspirin, folic acid and b6 and b12. She told me to do this for about 3 months and try again. She believes I will have a successful outcome. Infact she claims she has treated many women with this problem who have gone on to have very successful pregnancies. Keep the faith this is a treatable problem. I have already had 1 successful pregnancy without any treatment at all (because I was unaware until I got older I had this problem). So yes I am somebody who has this and everything turned out fine!! Good luck and as I said keep the faith!!! Debby
Hello all. As sad as many of our situations are, it is a blessing to find a support page with women who are experiencing similar issues. I am 30 had a blighted ovum last December, miscarried at 9 weeks in August and found that I have a prothrombin gene mutation and the MTHFR C677T mutation (heterozygous for both).
The game plan for the next preg is lovenox and continue my prenatal vitamins. (not to mention no birth control pills ever again :-) I am with many of you with the lingering question---will I ever have successful pregnancy?
I appreciate all of your posts as they are supportive and it is nice to hear stories from real women and get my head out of the literature and studies searching for a ray of hope.
Good luck to all and my prayers for each of you. Mandy
I have a perfectly healthy 4 year old boy. I am homozygous MTHFR/C677T and have Protein C Resistance. I take 81 mg baby aspirin, folpex, vitamin b complex, and a prenatal vitamin daily. After trying for a second child three years, I went to a reproductive endocrinologist who tested me for MTHFR after hearing my family medical history. He said that it was worth being infertile to find this out! I have taken Clomid, done 2 IUIs and no success (this after trying 3 years naturally). I am really frustrated because I can't even get a positive pregnancy test. I fear there's more to my story. But why did I have such a good first pregnancy??? It did take 8 months the first time. My MD says I will do Heparin shots daily if I get pregnant.
I haven't never heard of C6772, but I also have a heathy 5 year old daughter. My husband and I have been trying for almost 4.5 years with no luck and only one accident happened when I concieved her. I don't understand why it's so hard for me to become pregnant. I am starting on my ovulex in the morning and my husband is going to do the amberoz. I hope it works.
I had 4 miscarriages before having my daughter,(who is 2). I was tested for factor V and was negative in 2002. I have been trying to get pregnant for a year and just found out the I have 2 copies of the C677T/ MTHFR. I took baby asprin for 18 weeks with my daughter and had no complications at all. The doctor said when I get pregnant he will give me Lovenox and heprin shots. It was great to find this site, I hope to hear great outcomes for everyone!
Hi, I have had 3 miscarriages in the past year and one ectopic pregnancy 2 weeks ago. it has been so hard. Finally a Dr found out that both I and my husband are MTHFR heterozygous. He told us that we therefore have a 25% higher chance of miscarriage because if the foetus is homozygous it cannot survive. Is this true? Everything I have read only talks about homocysteine levels being important in the mother. Does anyone have informayion on this? What is Lovenox? a blood thinner? My husband also had a heart attack this year - at age 41 (this has not been a good year!) and I am wondering if this could be part of the problem for him also. He actually had 2 cardiac arrests due to excessive blood clotting. i'm wondering whether he should have his homocysteine levels checked, rather than just knowing that he is heterozugous for the mutation. Would folate and vitamin B also help him?
Finally, i'm worried about having a homozygous baby for the mutation. Does anyone know if this has been associated with developmental defects and birth defects even when the mother was taking vitamins and folate?
Sorry, these are a lot of questions. It's just so hard. I have been to see so many Drs before someone was finally prepared to even do this test and again I feel like he hasn't been able to give us a lot of information. I'm, sorry that there are so many women who have to go through this.
Kerstin- First about your husband, my dad had a heart attack at 38 and several blood clots, which back then they didn't know about the clotting disorders and he was just kept on coumadin, in 1989 he was tested and has factor IV and MTHFR, I have had 3 miscarriages , the first was at 9 weeks and they tested me because of my father and I have factor II and MTHFR(homo) they put me on extra folic, baby aspirin, and prenatal I am to take all 3 whether I am pregnant or not, my next two pregnancies I started 40mg of lovenox twice a day as soon as I found out, but still miscarried at 7 weeks and 4 weeks, I am currently almost 25 weeks and with this pregnancy the started the lovenox 6 days after ovulation and increased the dose to 80mg twice a day, they didn't test my husband. The disorder does cause some birth defects if you are not getting the folic and vitamins you need, if you are on the extra folic and prenatals before you get pregnant you should be fine, so far my baby is doing fine, but only God knows the outcome! I wish you luck and hope everything turns out with you and your husband!!
35 yrs old, dh is 38,married for 5 years on May 20th. have been ttc for 3 years, 3 miscarriages diagnosed with homo MTHFR and factor II mutation, trying on our own, did have one IUI but failed. BFP 7-21 05
Hello, We are probably not adding too much here, because we just found out that my wife tested above average for IGM (18) as well as tested positive for two copies of the C677T Mutation. So far we have done numerous IUIs and 3 IVFs. The 2nd IVF was a pregnacy, but unfortonately miscarried (9 weeks). After begging for answers and with a little research on the internet, we asked our doctor to run a test which he says 2% of woman have. I guess this could be our smoking gun??? Any suggestions on what we should do next? Why can't doctors test for this right away? Why all the pain we need to go through??
I had three miscarriages - one right after another - until I went to a fertility specialist who told me I had the MTHFR mutation (heterozygote). My doctor prescribed 4 mg folic acid (and prenatal vitamins) and once I got pregnant again, I was told to take a baby aspirin a day. I had a very healthy pregnancy (40 weeks exactly) and my daughter was born 8 lbs. 5 oz. It almost seemed too good to be true - just taking a few pills a day to help me keep my pregnancy, but it worked!
I am in need of some direction/advice. I also have the mthfr c677t gene. My son, Jake, was stillborn 11/07/04 at 34 weeks. After which the gene was discovered. I am now pregnant again. My specialist has prescribed lovenox, which our insurance company has denied. Heparin was also denied. I would tend to believe we have good insurance. My husband is a firefighter with the State of California and we are covered with Blue Shield. Has anyone had this happen? I feel so frustrated as these injections could be the answer to a successful pregnancy. Any advice on what to do w/ the insurance company? I feel like calling every newspaper, television station and consulting a lawyer. Help!
I just found out that I have the C677T Mutation. I was only tested because I have a family history of blood clots. I have had two completely normal full term pregnancies. I am 14 weeks pregnant and a lot more afraid of miscarriages this time around. I am going to a hemotologist this week for a treatment plan. I have also had no trouble getting pregnant, in fact, this third pregnancy was unplanned. Good luck to everyone.
Hi I have one abnormal gene and my husband has two. I had two miscarriages at 10 weeks before they tested then was told by my ob to take extra folate. But decided to do some research myself and found that I should be taking B6, B12 and baby aspirin, i really didn't want to have another miscarriage so i told my ob i was also going to take the asirin and the vitamins and she said that was fine. Through this whole experience i have felt noone really knows anything about this and if you want to find out anything you have to find it out yourself. Anyway good news i now have a 13 month little boy and am pregnant again, 8 weeks, i am still scared. I went to the doctor today and he told me i shouldn't be taking asirin it causes miscarriage so i am back researching (i shifted town so had to change doctors). I also have a question, last time i was pregnant i was told to stop taking the asirin at 36 weeks, i was so scared something would happen to the baby but he was fine, when are you told to stop taking the aspirin. anyway i only started taking the med after i found out i was preg so hopefully everything is alright with this one
I am the mother of 2 sons - born 11 years apart - not by choice. I suffered through numersous miscarriages between my 2 sons at least 2-3 each year to the point where I felt they were routine. The genetic testing for the blood clotting was not taken until after my treatment for breast cancer was completed. To have not known for all those years why i could not maintain a pregancy was the worst part of those years. After loosing a daughter at 14 weeks and the depression that followed made me give up the desire for children. Luckily while going through a career change I was able to carry my wonderful second son to term. That this test is routine after just a few miscarriages is a blessing. I am now on the same regiment of vitamins with my post treatment cancer drugs as well as having my sons tested (one of which was also postitive).
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