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Dr Shivani Sachdev Gour explains how MTHFR Mutation affects infertility

Dr. Shivani Sachdev Gour is a well known name in Indian Medical scenario. She shares her knowledge for the benefit of mankind. She informs her about a vital gene MTHFR. The methylenetetrahydrofolate reductase (MTHFR) gene converts homocysteine into methionine which is responsible for creation of healthy sperms and eggs in human body. It is also responsible for producing protein in the body.

If there is some asymmetrical change in gene structure, it is called gene mutation. MTHFR gene mutation means that it is unable to process B vitamins. The common gene mutations are C677T and A1298C. While A1298C MTHFR mutation affects 20 to 30 percent of the people across the globe, C677T MTHR mutation is linked to 5 10 percent of the population.

MTHFR gene mutation is closely linked to pregnancy loss. Some people with MTHFR gene mutation face homocysteine issues. One of the main reasons for recurring miscarriages is MTHFR gene mutation as it causes blood clotting. Couples with long standing infertility are tested for this gene mutation. Abnormal embryonic implantation and development is a result of defects in DNA maintenance methylation in the embryo. This helps us to understand EPL i.e. early pregnancy loss.

One can maximise the chances of conceiving a healthy pregnancy with a pre-conceptual assessment and supplementation regime for the couple. She advises all the intended parents to consult an expert naturopath. Dr. Shivani Sachdev Gour advises all the couples who are facing recurrent miscarriages to look beyond partners genetics and womans physiology. In a developing child, there is a huge risk of blood clotting which is directly linked to fathers genetics. Dr. Shivani shares her knowledge with all of us and wishes you all a safe, healthy and happy pregnancy.