Dr. Jacobs- I just wanted to say thank you for all of your advice. I am not sure if you remember me, but I am doing my first IVF after being cancelled in Dec due to a cyst after using the lupron. So right now I am cyst free and have already started my stims. I have been using Repronex along with gonal-f pen and lupron. I have not had a problem with any of the other medications (gonal pen is easy and lupron is no problem to draw up) but I am having some trouble mixing and drawing the Repronex. The first two nights I was on a half dose 37.5. I was told to mix 2cc's of the solution with the powder then draw only 1cc in the syringe to inject. The problem is with the syringe, the plunger has a mind of its own and seems to slide back when I attempt to draw the solution. I followed all the directions and even reviewed them with my RE this morning but it didn't help. I make sure the needle is always in the liquid and not in the air, but that is not working. Eventually I get it done, but it is not easy. Tonight I was told to take the full dose 75. I was told to draw only 1cc to mix and take the full amount. Well tonight I had major problems and had to throw away an entire dose and start over. When I added the solution to the powder it bubbled up like soap suds on the top of the liquid. I know there were no bubbles in the solution when I drew it into the syringe to add to the powder, so I am not sure what when wrong. When I tried to draw the mixed solution into the syringe to inject I had major suds and was nervous to use it and threw it away. I started over and it seemed fine. Other than the problem with the plunger on the syringe sliding on its own. Is there something I am doing wrong? Could it be the syringe I am using (3ml 22g 1 1/2 inch needle) to mix or could there have been something wrong with the actual medication? I am not sure if the problem I had with the dose I threw away is related to the problems I have been having all along with the syringe. Any insight that would help make this easier would be appreciated. Thank you so much for your time! You have no idea how much you are appreciated.