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I have had three pregnacies over the past 3 years, all of which seemed to happen pretty easily. One ended at 5 weeks, another was a chemical pregnancy, and the last one ended at 11 weeks with a missed miscarriage. My menstrual cycle is very regular at every 31 days. I have since been trying to concieve for the past 1yr with no luck. I do also have one child who is now 8.

I have had positive antiphospholipid antibodies in the past, but are now negative. I am also positive for the MTHFR mutations and was put on extra folic acid and was recently diagnosed with pre-diabetes for which I take metformin.

After seeing a RE for repeated miscarriages he found my endometrial biopsy to be out of sync. He recommended clomid with timed intercourse. I tried 4 cycles of the clomid. The first two cycles I produced 2 nice size follicles on 50 mg of clomid, but did not achieve pregnancy. The third cyle I only produced 1 follicle on the 50 mg of clomid and was told I had low progesterone at 7 dpo. I was put on 200mg suppositories until a negative hcg result. The fourth cycle he increased the clomid to 100mg. I still only produced only one follicle. He recommended I move on to injectibles (gonal -f). The RE has me on 150 iu injections for the first 3 days then I am to return for bloodwork and u/s. I am very concerned about overstimulating my ovaries since I already ovulate on my own. Is this dose high for a first cycle on gonal-f with my history? The RE who recommended this dosage is not my regular RE, it is his partner. My regular RE is on vacation. Any information you can give me at this point would be very helpful. Thank you.

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