letrozole
1 Replies
fplgiraffe - April 26

While reading about IUI ovarian stimulation protocols, I came across the Canadian study by Biljan et al. suggesting that letrozole is associated with a higher rate of congenital malformations--although a subsequent US study suggested no significant increased risk.

What is the general consensus among RE's in the US regarding this drug? Has it fallen out of favor? Or are a lot of RE's still using it in their protocols? Do you use this drug much in your practice?

 

B. Jacobs, M. D. - April 27

Letrozol is probably a very good product for ovulation induction, and probably does not increase the risk of birth defects. The manufacturer did not seek FDA approval for that use of the product, and has declared that it will provide no assistance to anyone who prescribes it for that purpose, and has an adverse event. Many of us are concerned about that possibility.

 

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