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The estradiol concentration is a reflection of th etotal number of growing follicles, but therte is not an exact relationship. Generally speaking, each mature follicle contributes enough estradiol to produce a concentration of 250 to 350 pg/ml. Please also note that smaller grownig follicles also contribute estrogen.

How does one correlate Follistim dose, #days of stimulation, # of follicles and estradiol level as a measure of successful stimulation?

I am afraid that is part of the "art of medicine". Determining the adjustment to the dose of FSH is largely a matter of experience. There is no formula.
Good luck.

Does one typically only see an estrogen spike once the follicles are "mature" or does estrogen rise throughout the maturing process? What could a decrease in estrogen indicate in the presence of growing follicles? Also, is the 250 - 300 range PER each mature follicle or for mature follicles in general? For example, with 3 follicles should the estrogen level be 250 - 300 or over 750? Thank you for your contributions to this board!

We think that total estrogen production during stimulation is close to 250 to 350 pg/ml for each large follicle. As far as the drop in estrogen during stimulation, I can only speculate.
Good luck.

Dr. Jacobs is it possible not to have any symptoms at all after the transfer, I had my transfer on 11/21 , three days afer transfer I mild cramps and that is about it. I am doing the 1cc progesteron shot each nite. my bbs are a little on the heavy side, and I do feel some how feverish, I have not had any actual spotting or bleeding... thank you grace.

Please, what are some of the reasons that would cause estrogen to decrease in the presence of growing follicles? There must be a differential diagnosis to consider in these situations. Thank you.

I really cannot speculate. I do not know all the parameters to make a meaningful guess. Your own RE is in a far better position to answer your question.
Good luck.