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Red7 - June 17th, 2008 2:28 PM

Hi DR. Jacobs which product is better on the uterus Lining, by building it up. Endometrin or Crinone 8% gel? In your opinion? Thank You.


B. Jacobs, M. D. - June 17th, 2008 4:50 PM

Crinone and other vaginal progesterone preparations go directly to the endometrium, and produce a good tissue level, without a significant increase in blood level of progesterone. Absorb tion and blood level of oral progesterone products is very unpredictable and not very reliable. Taken orally, you need a significant blood level of progesterone to get an adequate tissue level. After all, you really need the progesterone in the endometrium, not the blood.
Good luck.


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