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tatty - August 6th, 2006 10:49 AM

Hi Dr Smith,

My partners semen analysis always shows a high round cell count, his last one showed 15 million/ml round cells. Count was 13 million/ml.

His hormone levels have come back normal and he has been treated with antibiotics twice, once with doxycycline but still they remain high.

Should we be worried about this ?, will the high round cell level be affecting count/morphology/motility ? The analysis mentions peroxidase positive.

Any advice would be appreciated.

Regards,

Tatty


Dr Smith - August 8th, 2006 10:35 AM

Sometimes, UTI's in men can be difficult to treat and resistant to antibiotics. The high concentration of white blood cells (a.k.a. round cells) can adversely affect sperm function. In these cases, IVF/ICSI is the usual treatment because the "good" sperm can be isolated and injected directly into the egg. This overcomes the potential negative effect of the high WBC's.

Peroxidase staining is a method of differentiating WBC's from other "round" cell in the ejaculate. Peroxidase positive means the round cells were positively identified as WBC's.

tatty - August 13th, 2006 1:19 PM

Hi Dr Smith,

Is there no other course of action/treatment to reduce these WBC's? e.g try different antobiotics?

Many thanks,

Tatty

Dr Smith - August 14th, 2006 11:14 AM

UTI's in men as difficult to treat, as they are often resistant to a variety of antibiotics. After about three different antibiotics, most docs give up. Men with UTI's are often asymptomatic. They never know they have one until they have a semen analysis. If you are trying to conceive naturally, this is probaably a contributing factor to your infertility. If you are doing IVF/ICSI, it doesn't really matter.


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