repeated failed IVF with good quality embryos
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nikidb - November 2

Hi there. Thank you for hosting this forum. I am 36 years old and have just completed an unsuccessful IVF cycle. I started stimulation on Oct 7 (day 4 of my cycle) with 75 units of repronex and 75 units of puregon - my estradiol levels were very high (3255 on day 7, 18912 on day 11, 23604 on day 12...) and I am a good responder. Due to estradiol levels, I coasted for 2 days prior to my HCG injection. 16 eggs were retrieved, 12 were mature and injected (ICSI) and 8 fertilized. On day 5, 1 early blast (quality A) was transferred and on day 5 two other blasts were frozen (one early blast B+, and a 3B+,B) and on day 6 a third blast was frozen (3A B+). I got my period today so the cycle was unsuccessful. My concern is that I might have an implantation issue. I did my first fresh IVF cycle three years ago and we had nine great quality eggs - 1 blast (2 AA quality) was transferred but I got my period before the pregnancy test. Two other blasts were frozen along with 6 day1 2pn embryos. My clinic transfers one embryo at a time for me - I have had a myomectomy six months prior to my first IVF that required a full transabdominal cut. The first FET (day 3 transfer) with an 8 cell A quality was negative. The second FET (3 day tansfer of 6 cell A-) was positive and I gave birth to my beautiful daughter in Oct 2007. I tried other FETs with the remaining eggs - all good quality and all negative result. The clinic seems unconcerned but I think that it is strange that even with good quality embryos I seem to have great difficulty getting pregnant. Thye tell me that this is just due to an arrest of growth and nothing else due to some inherent problem in the embryo. I am not sure what to think - I always do the FETs medicated with crinone as the progersteron supplement. Do you have any thoughts?

 

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