Re: Overstimulation
2 Replies
Lana - October 3

Dear Dr Smith
I've written to you before about our slow growing embryos, and reading one of your other mails just raised another question.

The last round I was stimulated with Gonal F and Menogon as opposed to clomid (iso gonal F) in my previous 3 IVF's. I'm now pretty sure that this 4th IVF also failed despite my blood test only being on thursday...I know my body by now.

I didn't mention before that I have only one ovary (other one removed at 15yrs old) - and from this they retrieved 14 eggs this cycle of which 12 fertilized. We were very excited about this 'success' at first, but then saw our embryos all basically arrested at compact stage (incl apparently the ones they transferred).

You've confirmed to me earlier that it may be worth stretching out the stims to align it closer to my natural cycle, but would you agree that less drugs may also in fact give us a better result ito egg quality (vs quantity)?

I wasn't officially hyperstimulated this time but I think I was pretty close to it, was feeling extremely uncomfortable just before and for a good few days after retrieval.

 

Lana - October 3

Dear Dr Smith
I've written to you before about our slow growing embryos, and reading one of your other mails just raised another question.

The last round I was stimulated with Gonal F and Menogon as opposed to clomid (iso gonal F) in my previous 3 IVF's. I'm now pretty sure that this 4th IVF also failed despite my blood test only being on thursday...I know my body by now.

I didn't mention before that I have only one ovary (other one removed at 15yrs old) - and from this they retrieved 14 eggs this cycle of which 12 fertilized. We were very excited about this 'success' at first, but then saw our embryos all basically arrested at compact stage (incl apparently the ones they transferred).

You've confirmed to me earlier that it may be worth stretching out the stims to align it closer to my natural cycle, but would you agree that less drugs may also in fact give us a better result ito egg quality (vs quantity)?

I wasn't officially hyperstimulated this time but I think I was pretty close to it, was feeling extremely uncomfortable just before and for a good few days after retrieval.

 

Dr Smith - October 5

The dose of stimulation medication, per se, does not affect egg quality. The dose of stimulation medication modulates the rate of growth of the follicles and therefore, indirectly, affects egg maturation. Stretching out the stimulation beyond 12 days by using a low dose can also affect the eggs in an adverse way. So a lower amount of medication does not directly translate into better quality eggs. The dose of medication should be adjusted so that the stimulation takes 9-12 days.

 

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