PGD/ chemical pregnancy
1 Replies
jgf - July 17

HOw common is it to have a chemical pregnancy after doing PGD? We transferred 3 blasts that passed PGD.

 

Dr Smith - July 18

PGD is still relatively new, so there isn't enough information out there to answer your question with any degree of accuracy. PGD, at best, only detects abnormalities in the number for 11 of the 23 pairs or chromomses. If there is a problem in any one of the other 12, PGD will not identifiy it. Moreover, PGD has a significant margin of error. I think PGD has been hyped and has led to unrealistic patient expectations. PGD using the FISH technique only scratches the surface of potential genetic problems that affect embryo development. I suppose, if your only tool is hammer, the whole world is a nail. Genetic problems that cause embryos to arrest development after implantation are likely caused by subtle genetic problems (point mutations, etc.) that would not have been detected by PGD with FISH. The good news is that new technologies are being developed that may provide more indepth analysis of the embryonic genome.

Uterine factors can also cause biochemical pregnancies. It would be prudent to be checked for any autoimmune problems that may be interfering with the continuation of a pregnancy.

 

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