Immune Testing in non pregnant state
1 Replies
RICHMONDTB - January 4

Hi
At our last clinic, we miscarried a donor egg embryo at 5 weeks.

There was a sac visible but no yolk sac. The reasons given by the Re were immune issues, sperm issues and genetic abnormalities.
Which we have since left that clinic.

Unfortunately the miscarried embryos were only cultured to 51 hours and from reading this board, the sperm comes into play or the sperm adds to the genetics on day 3, but given the sperm was a reason for the miscarriage
can this be true knowning little about the sperm.

I have since been tested by a hematologist for immune issues and in a non pregnant state, he said there were no immune issues at all.
So can immune results vary in non pregnant state or pregnant state and if so, which is more important?

I do have the MTHR, but I think it is homogeneous issues
Only one cell is defective.

Also what impacts fertilization of embryos?

thanks
Brenda

What f

 

Dr Smith - January 8

Well, from what you presented, your previous RE was correct in that your miscarriage could have been caused by any one of the three reasons suggested. I think, because there was no yolk sac, the miscarriage was caused by abnormal genetics of the embryo. These genetic abnormaliteis could have come from the sperm, the egg, or both. Just because the egg came from a donor doesn't mean it was genetically normal. Donors can have abnormal eggs too. You cannot assume that the miscarriage was caused by the sperm.

The presence of an abnormal number of NK cells and/or abnormal activation of NK cells is not dependent on pregnancy. It does not change during pregnancy.

 

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