good eggs but slow embryos?
70 Replies
jzk1 - September 14

Well I'm turning 40 next week my husband is 36 we've been seeing RE in 4 different states at major university centers and just completed over the last 5 years 3 IUI's 1 GIFT and 6 IVF's I feel like I've been through a war. I'm covered in bruises my ovaries are aching and my heart is broken. Today I transferred back two 4 cell day 3 embryos and am certain of the outcome I have always had fragmented eggs up to 25% but this is the first time they are not dividing properly, there comes a time you have to throw in the towel. My work up was completely normal husband had varicocele repair 3 years ago with now normal seman studies except HOS we even tried the endometrial coculture today which clearly did not help we are both in healthcare and have utilized every medical contact we have. I guess I just need closure and am tired of venting and crying. Crying for all my little babies that are in heaven and hopefully for all you other prospective mommies.. Good luck to you all

 

jzk1 - September 14

Well I'm turning 40 next week my husband is 36 we've been seeing RE in 4 different states at major university centers and just completed over the last 5 years 3 IUI's 1 GIFT and 6 IVF's I feel like I've been through a war. I'm covered in bruises my ovaries are aching and my heart is broken. Today I transferred back two 4 cell day 3 embryos and am certain of the outcome I have always had fragmented eggs up to 25% but this is the first time they are not dividing properly, there comes a time you have to throw in the towel. My work up was completely normal husband had varicocele repair 3 years ago with now normal seman studies except HOS we even tried the endometrial coculture today which clearly did not help we are both in healthcare and have utilized every medical contact we have. I guess I just need closure and am tired of venting and crying. Crying for all my little babies that are in heaven and hopefully for all you other prospective mommies.. Good luck to you all

 

walkeai - November 2

Dr. smith-forgot to mention, these were donor eggs from 29 yr. old, 3rd time donor.

 

walkeai - November 2

Dr. smith-forgot to mention, these were donor eggs from 29 yr. old, 3rd time donor.

 

anonymous - October 25

32yrs. old. 28 own eggs, 13 mature, 8 fertilized using ICSI (male factor due to 20 yr. old vas reversal fail). Day 5: 3 arrested, 1 blast, 1 early blast, 2 morulas, one PN (there's some confusion there). Transferred the two blasts, BPN result. The rest grown to Day 6 blasts and frozen.
Today: 44 yrs. old. Slow growing embies frozen with standard freezing, for nearly 12 years. What is the reality?

 

sam-willie - April 2

Hi,
I'm looking for some information, I'm on my first IVF cycle, I have just had embryo transfer today(day 5) I had originally 8 eggs, 7 fertilised all high quality until day 3, they still had 4 which were doing really well, all still high quality, I arrived today for my transfer and was told that none had made it to blastocyst, 1 was at compaction and the other wasn't far behind so they decided to transfer both of them as the other ones aren't as good and are so far unsuitable for freezing but the embryologist said she would keep them till tomorrow just in case they decide to show off and catch up as one was at 12 cells and one at 11, what is my chances of a successful pregnancy with the 2 I have had transferred?
My history is 4 m/c's, 3 ectopics, both tubes removed now.
Husbands sperm is champion apparently
My eggs were good quality
my AMH was 21.6
I am 31 in July
DH is 27 next week
I have a healthy 12 year old daughter from a previous relationship
Just need to know what my chances are.

Thanks
Samantha

 

sam-willie - April 2

Oh I always miscarry at around 5 weeks

 

RVK20100105 - March 12

Dear Dr Sam:

My wife and I have just undergone our 6th failed IVF:

IVF #1 - Dec 2012 (Wife aged 34 + 1 month) - 10+ eggs with only 1 blastocyst. Transferred 2 and BFN
IVF #2 - Apr 2013 (Wife aged 34 + 5 months) - 10+ eggs with no blastocysts. Transferred 2 morulas but BFN
IVF (ICSI) #3 - Aug 2013 (Wife aged 34 + 9 months) - 34 eggs, 23 mature, 18 fertilized, 5 made it blastocyst / hatching blastocyst by day 6 and we did aCGH but 4 were abnormal and only 1 normal - BFN
IVF (ICSI) #4 - Nov 2013 (wife aged 35) - 14 eggs, 12 mature, 11 fertilized, 2 made to day 6 blastocyst, but were both abnormal under aCGH
IVF #5 - July 2014 (wife aged 35 + 8 months) - 11 eggs, 9 mature, 7 fertilized. 3 were 6-8 cells by day 3 but none made to blastocyst
IVF (ICSI) #6 - Mar 2015 (wife aged 36 +4 months) - 12 eggs, 8 mature, 7 fertilized, none made it to blastocyst. In fact the most developed after 6 days was 6-7 cell, so it probably stopped at day 3?

Our biggest question is on embryo development since we NEVER got 30% to blastocyst even in the first 1-2 tries when my wife was still 34.

1) Is it the lab? I don't think it is a lab issue because they managed to get us to blastocyst in the past.

2) We are wondering if it is a mitochondrial issue or DNA issue. One hypothesis is embryo DNA issue since it has developed to day 3 but we have had high aneuploidy ratio in the past with aCGH. However, we tested our Karyotype and both are normal, so it is probably a function of the sperm quality or egg quality?

- On the sperm side, I am 40 and have borderline sperm quantity / motility with poor morphology (count ~60mn/ml, motility ~50%, normal forms ~2%). I never got tested for sperm DNA fragmentation but I guess it could also be an issue. In any case, this time we did it with magnetic assisted cell sorting so I guess it would have got rid of some of the poor sperm?

- On the egg side, my wife's AMH is high at 5.16ng/mol. So quantity is not an issue - everytime the doctor sees her he thinks ovarian reserve is good. But this time, the doctor seemed very disappointed with the collection of 12 eggs as he would have expected 20 - seemed like poor response. We have always been on short antagonist protocol so maybe we will try the long agonist protocol.

Once again, we are sorry to impose on you but we don't know where to turn for help. Grateful for any wisdom you can share.

Thank you!

Expecting RVK

 

ADV2014 - July 22

Hello,

My partner and I are both 28 years old and tried to get pregnant naturally for 6 months and then with the help of Clomid and IUI for the remaining 6 months but nothing worked. One time by fluke we ended up having a chemical pregnancy.

My AMH is perfect and right on where it should be for somebody my age. My husband has very high sperm counts and most of his tests have been good. His DNA fragmentation came back at 11% and the same DNA fragmentation test for some odd reason came back with low motility and low morphology. He has done one regular semen analysis, two IUI washes and the IVF wash and everything seemed to be normal. Our doctor was a bit concerned that for a patient of 27/28 the DNA shouldn't have been 11% but she expected it to be 0-5%.

I was an excellent responder to the IVF stims, our goal was 15 retrieved and we had 16 retrieved, 13 were mature. We did ICSI, on day 1, we had 9 fertilize normally and 4 abnormally. By day 3 we had only lost 1, so we had 8. We were told we would probably end up with 5 as at least 3 had 25% fragmentation. On day 6 we got a call that we had 3 embryos frozen which was so disappointing. We had only one AA make it to day 5 and two BA and BB make it to day 6.

Our doctor told us that it seems to be male factor as we had 4 abnormally fertilize right away and she mentioned between days 3-5 is the father's genes and it seemed something did not work out on his side. Do you agree with this?

I have been pregnant in the past with a different partner without even trying and having sex once. I don't seem to have any reason to believe it was an egg quality?

 

nicoleswishfulthinking - January 29

od Morning! Thank you for taking the time to answer so many questions for people.. this is definitely a long and stressful process.. My story 31. unknown diagnosis. Healthy weight, good thyroid. AT AGE 29, FSH has been 10.1 and 9.7 my amh 3.97 and I have 25+ follicles on each baseline u/s.. had a miscarriage (blighted ovum) in 2013. Did IVF in 1/2014. retrieved 21 eggs, only 8 were mature??? ( not sure if that reflects bad quality) all 8 fertilized. Fresh cycle failed. had 7 frosties put 2 in Feb and started with a twin pregnancy. Lost one at 9 weeks but delivered my daughter healthy in Nov 14. we did a ESET yesterday. They thawed an 8 cell grade A. It lost a cell during thaw but was 9A the morning of and was compacting into what the embryologist said was a blastocyst? Not sure, I thought they went to morula first. My questions are.1. is it an indication of bad quality if I only had 8 mature eggs? I used to be a smoker. 2. is it okay that my embryo lost a cell during thaw? Does that have any negative affects on my chances of conception? is it possible that it grew from a 7 cell embryo to a 9 cell then started compacting into a blast?

Also, is it beneficial that I have already conceived a child from this batch of embryos?

 

Message:


You must log in to reply.

Are you New to the forum? Sign Up Here! Already a member? Please login below.




Forgot your password?
Need Help?  
New to the forum?

Sign Up Here!


Already a member?
Please login below.





Forgot your password?
Need Help?  
Ask a Question