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Your chances are pretty good - around 50/50 for a term pregnancy. And you have the 4 frozen blastocysts to fall back on as well. Hang in there and try not to stress too much during your two week wait. Best of luck on Thursday.

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Dr. Smith
I am 40yrs old, I had 13 that fertilized. On the 5th day we transfered 5. I have been thru Ivf once before and it didn't take (transfered 4, but only got 6 good ones and did the transfer on day 3). The only reason we are using Ivf is because my tubes are tied. Just wondering what our chances are this time?

thanks

LillyO

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In order to advise you, I will need more information regarding the stage and grade of the Day 5 embryos that were transferred.

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thats the funny thing here.. I didn't even know they graded the embryos. The first I heard of it was in this sight?? As for stage I don't know that either..I was told there were all really good and they were very possitive.. There was 2 left to freeze the next day, not sure if that means anything or not. We didn't get a picture of the embryos this time, they said there camera was broken.. Thanks for answering thou..

Lilly

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Dr. Smith
I found out what the grade and stage of the embryo's were.
4aa
3aa
2aa
2ab
early?
and it was a day 5 transfer blast. It was like they didn't want to tell me. Not sure why? what do you think of my chances are? thanks in advance. Keep in mind I am 40 yrs old and my tubes were tied.


Lilly

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Dr. Smith,
First of all, thank you so much for this fabulous forum. Your precious time is greatly appreciated!

I recently had a retrieval where 19 eggs were obtained, 14 mature, and 10 fertilized. Of the 10, pgd was performed, there were three normals of the bunch ( I am 37). Of the three (Day 5), 2 were starting to expand, but not fully expanded (no grading aa,bb etc). And the other one was morula stage. We transferred all three (I've had 7m/c and 1 child from an ivf 3 years ago). With the third so far behind, and my hx of m/c, we felt comfortable that triplets are unlikely.

My concern is that my blasts weren't fully expanded. We did transfer earlier in the morning than when the retrieval was performed. Do you think a blast could expand in a matter of hours? Do you think I have a reasonable chance? Do you see pregnancies with pgd normal blasts that haven't fully expanded?

Thanks!

Amy

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Forgot to add, my most perfect looking blast, 4AA had MULTIPLE genetic abnomalities! Scary...

Amy

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Yes, blastocyst stage embryos really "take off". The expansion process occurs over the course of about 6 hours. I wouldn't be worried about the degree of expansion. The only downside I see is that they could not be assessed/graded. I find, although there is no hard data in the literature to support this, that PGD embryos take a little bit longer to reach the fully expanded blastocyst stage. I think it is an effect of the biopsy procedure, which necessitates breaking all the adhesions between the cells of the developing embryo (so that you can easily remove one of the cells for genetic testing). The embryonic cells have to reform these adhesions after the biopsy procedure and this takes a little extra time. Yes, I've seen pregnancies from blastocyst in the early stage of expansion following PGD. I think you have a reasonable chance. Time will tell.

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Dr. Smith
I found out what the grade and stage of the embryo's were.
4aa
3aa
2aa
2ab
early?
and it was a day 5 transfer blast. It was like they didn't want to tell me. Not sure why? what do you think of my chances are? thanks in advance. I go in tomorrow for pg test.. can't wait...

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The 4AA and 3AA are expanded blastocysts and we graded as top notch. The 2's were in the early stages of expansion, but sufficiently expanded to determine the grade of the inner cell mass - and they were graded a "good". So... I'd say your chances are pretty good.

Laboratory information is a closely grarded secret - don't ya know. Most RE's are extremely reluctant to release lab info to the patient. It opens the program to critism if evaluated by an embryologist at another program. In your case, they look fine. No worries.

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Thanks for answering Dr. Smith.. I really appreciate it. Well got the results and not pg. My hcg level was -2. He of course doesn't know why. any ideas, could the eggs have been bad? I don't understand if they lasted 5 days why wouldn't it work? Just alittle depressed..thanks in advance..


Lilly

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There are endometrial factors to consider as well (i.e. endometrial thickness, uterine blood flow, autoimmune issues, etc.). Have a chat with your doc to see if he/she has any insight. The other thing is that even when we transfer "good" embryos, there's still only a 50/50 chance of a success. It could also been just the luck of the draw.

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