Can embryos be frozen 2 times?
1 Replies
JudyY - December 12

I have 4 frozen embryos that were frozen the day after ER. I am currently doing a fresh IVF cycle now. I need to do PGD due to being a carrier of Duchenne Muscular dystrophy and it looks like we will thaw the frozen and test those at the same time as we test the fresh ones as it looks like I will only get 5-7 mature eggs this time. My question is if the 4 frozen ones are all good and we chose not to transfer them all or if the fresh ones are higher quality is it possible to refreeze the frozen ones again at day 5?

Thanks - Judy

 

Dr Smith - December 12

Yes. Embryos can be thawed and re-frozen. I've never done it, but there are at least three reports in the scientific literature regarding this procedure.

1: Smith LK, Roots EH, Dorsett MJ. Live birth of a normal healthy baby after a frozen embryo transfer with blastocysts that were frozen and thawed twice.
Fertil Steril. 2005 Jan;83(1):198-200.

2: Yokota Y, Yokota H, Yokota M, Sato S, Araki Y. Birth of healthy twins from in vitro development of human refrozen embryos. Fertil Steril. 2001 Nov;76(5):1063-5.

3: Baker A, Check JH, Lurie D, Hourani C, Hoover LM. Pregnancy achieved with pronuclear-stage embryos that were cryopreserved and thawed twice: a case report. J Assist Reprod Genet. 1996 Oct;13(9):713-5.

 

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