assited hatching
1 Replies
NANCY - March 3

If you do IVF with ICSI do you have a better chance of the embryo implanting if you do assisted hatching?

Thanks
Nancy

 

Dr Smith - March 4

Depends on the day of transfer. Assisted hatching for Day 3 embryos has been shown to be beneficial for patients >38 years old, those with a previous IVF failure and those patients whose embryos are surrounded by a thicker than normal zona pellucidae. Patients in other categories may or may not benefit from AH. Assisted hatching has been shown to be beneificial for blastocyst stage transfers (Day 5) in all patient groups.

ICSI makes a very small (3-4 micron diameter) hole in the zona pelluciade when the sperm is injected. Assisted hatching on Day 5 embryos involves making a hole approximately 30 microns in diameter. These are not equivalent procedures, so having ICSI does not negate the necessity of assisted hatching in patients that would benefit.

 

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