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aefthimiadis - March 10th, 2007 3:37 PM

I have to agree with Julia.....Lovenox is what got most of these women to be able to deliver healthy babies. Without it they probably would have never had a chance. I had two miscarriages and now I am trying again and so ready to attack this with lovenox and hold a healthy baby in my arms. My sister in law's baby died from meconium and she never had any other problems with her three deliveries.


aefthimiadis - March 10th, 2007 3:40 PM

I agree we don't need anymore fear and negativity we have enough of it. There is also risks in epidural and so many pregnant woman receive it at delivery.


phoenixmama - March 11th, 2007 12:07 AM

Heather, I am so sorry to hear about your losses. My second pregnancy ended at 36 weeks when my son was stillborn. I had a c-section and after that I had a PE, but don't have any clotting disorders. I'm on Coumadin now anyway (until May) for treatment for the PE and I too would like to get pregnant after getting off of the Coumadin. I will be on Lovenox when I get pregnant too, but the two pregnancies I've had so far have been full-term and otherwise healthy (even though my son passed due to a defect) and I wasn't on Lovenox then so I can't really help you with that. I would definitely bring it up with your doctor though, the fact that you weren't on that much while you were pregnant. It doesn't seem like you would need that much before pregnancy. I was wondering how long your doctor told you to wait after stopping Coumadin before you could get pregnant?


HopefulinNY - March 11th, 2007 11:11 AM

[quote author=HopefulinNY link=board=13;threadid=1981;start=480#33193 date=1173455341]
Hi I am new here. I have battled infertility for 8 years. I am doing my first IVF and the doctor told me today he is going to start me on Lovenox on Monday, and thursday is my FET (frozen transfer, couldn't do fresh due to Ovarian hypterstimulation).

I am so scared and nervous. I don't know why I'm always petrified of doing new meds, and a blood thinner seems so dangerous?

Should I have any concerns and what advise does anyone have for me?? I am willing to do it because I want a child, but I also need to relax and stay calm.

I have read so many posts and it has made me feel better, so any additional advise would be great.
Thanks
Clara


[/quote]

I
s
there an equal dosage of aspirin I can take to be equal to 40mg of lovenox?? I have to admit this is all made me scared stiff, and I don't know what to do after my transfer on Thursday?


amyjoy - March 11th, 2007 9:04 PM

Hopeful-
I am not aware of a dose of asprin equal to Lovenox. Lovenox and asprin are abosorbed differently by the body. You should discuss everything with your Dr. and make a choice you feel comfortbale with.


Miicki - March 13th, 2007 10:46 AM

PrincessB- you are shaking things up---haha--actually i think if anything people just like hearing positive stories & experiences. But on the flip side- if you have info that you want to post- you totally can- a lot of us are in the same boat so new information is better than none. A lot of women are already scared or nervous so negative information may be hard to hear from just one person.. But i am assuming all the women on this site have gotten their information from their DR & they are choosing to use Lovenox after being educated- it's up to everyone to do more research if they want to or if they feel comfortable w/their dr- it's their decision- i also agree there is a risk with any medication you take & as someone said- an epideral & a lot of women get those---
No 1 person's situation is the same so it's so hard to compare yours to everyone elses who are currently using lovenox- It would be heartbreaking to have a child with disabilities-
So if anything- try to give us information that can be positive too or if it is negative- is there any more recommendations. I trust my dr 100% and i wouldn't be doing this if i didn't feel confident- but on the flip side I am nervous too like most of the people on this site.

Julia C-- a triple marker is a great non-invasive test that can reassure you about a few things- 1) any neural tube disorders 2) downs- those are the biggies. It's a blood sample & if you are older than 35 i think it's done automatically- if you are younger, you can choose to do it or not- i would suggest everyone doing it b/c it's just a blood test. why not be reassured by the results. it may take a few days to get back.


Miicki - March 13th, 2007 11:01 AM

Who is in their last month of pregnancy? and if you are on lovenox now, have you switched to heparin or anything else prior to the birth? lastly- anyone not been diagnosed with a disorder & are using lovenox b/c that was kind of your last effort to sustain a pregnancy?

I am being switched to heparin- 2 Xs a day at 7500 at week 36. I have no known blood disorders or anything else wrong- just 4 m/c with no known reason after a lot of testing.

I just wanted to see what everyone else was doing for reference- My RE suggested this dosage to my OB/GYN.


Thanks


PrincessB - March 13th, 2007 11:22 AM

[quote author=HopefulinNY link=board=13;threadid=1981;start=510#33279 date=1173625877]
[quote author=HopefulinNY link=board=13;threadid=1981;start=480#33193 date=1173455341]
Hi I am new here. I have battled infertility for 8 years. I am doing my first IVF and the doctor told me today he is going to start me on Lovenox on Monday, and thursday is my FET (frozen transfer, couldn't do fresh due to Ovarian hypterstimulation).

I am so scared and nervous. I don't know why I'm always petrified of doing new meds, and a blood thinner seems so dangerous?

Should I have any concerns and what advise does anyone have for me?? I am willing to do it because I want a child, but I also need to relax and stay calm.

I have read so many posts and it has made me feel better, so any additional advise would be great.
Thanks
Clara


[/quote]

I
s
there an equal dosage of aspirin I can take to be equal to 40mg of lovenox?? I have to admit this is all made me scared stiff, and I don't know what to do after my transfer on Thursday?
[/quote]

Dear Hopeful in NY: I am so sorry for your struggle with infertility and this drug has provided mothers hope but it of course does not come without risks. It could be just fine: esp. if the dr. is trying to go with the absolute lowest dose possible.

The reason doctors want to use a blood thinner on women with coagulation disorders is because of the increases of weight, blood volume and risk with pregnancy. Preventative thinning helps to counteract the thickening that is produced with various stresses on the body: such as the one that produces Cortisol (stress hormone) in the body which is a very "clotting" and "clogging" substance in large doses or over long periods of time. So understanding how important it is to breathe, relax, and try not to stress yourself is very important: good on you!

The concept of thinning the blood is an excellent one for that reason. There are some alternatives to discuss with your doctor - and these aren't just for during pregnancy - it's an overall wellness approach for women with clotting disorders and of course would require monitoring and as-needed anticoagulation with an Rx if you have a clot or flare-up. But for prevention, I've seen this work as well as any Rx out there and I've spent years with specialists on these approaches.

Perhaps you could print this and discuss it with your doctor, not in an effort to get you completely off of Lovenox, but to use Lovenox as a short-term treatment for ons-set, in it's lowest dosage or as a weapon in your arsenal to be used in moderation for a period of time not longer than 3 weeks:

1) low dosage baby aspirin: it also comes with risks including liver problems and complications - but can and should be discussed.
2) Women with clotting disorders must avoid sedentary lifestyles and sedentary positioning for hours (this can range from constantly being reclined without circulation to sitting for long periods at a desk in front of a computer. The more circulation and safe activity you can offer, the more your body will have circulated oxygen - and practicing deep breathing regularly during the day will also help oxygenate the blood and circulate it. An airline study of DVTs showed a major positive correlation not strictly with the sitting on the planes and DVT: but the lower oxygen levels in the blood combined with the poor circulation. So the net-net for a pregnant woman is combining appropriate and regular movement with deep breathing and fresh air: LOTS of it. Bed rest can be the enemy for a clotting disorder.
3) For women in the lower range of weight gain, good health and the ability to get light exercise, such as 20-30 minutes of walking or swimming or moving around in a pool twice a day, you optimize your ability to reduce your own clotting factors. Gentle movements repetitively for those confined to bed is absolutely critical to avoiding onset of a clot. I've heard about a DVD called Yoga In Bed but can't recommend it as I haven't seen it or tried it yet. Just an FYI.
4) I'm all for a cup of green tea or decaf or a little chocolate - esp. dark chocolate more than 70% cocoa for the antioxidants but you must avoide caffeine at all costs. It is a potent vasoconstrictor - and you need to prevent anything that causes vessels to constrict.
5) Decongestants are also very powerful vasoconstrictors, such as long-lasting cold medicines and allergy products. These must also be avoided.
6) Modify your diet with a diet rich in foods that have vitamin E - such as biologically active tocopherols - 400 IU a day will thin the blood nicely, and as you gain weight you can go up to 600 IU. The naturopathic physicians I have worked with say 800 is getting really on the high end and can cause complications much like an overdose of other thinners, but might be appropriate for heavier-weight ratio pregnancies. Of course, you'd recognize symptoms of over anti-coagulation which could range from tiredness, dizziness, etc. - your body can typically tell you how much is too much for you when you get to knowing and listening to it. A couple of handfuls of almonds per day are a nice way to pack in your vitamin E foods. You can do an internet search or pick up a few good books on nutrition to pinpoint three essential types of friendly nutrient foods: your vitamin E foods, your vasodilating foods and your foods that maximize absorption of vitamin E foods: a concept called nutient pairing. This is your body's best way of assimilating what it needs to run happily while mitigating risk.
7) Here are the really hard ones: NO HIGH FRUCTOSE CORN SYRUP. It's a liver toxin and a genetically modified corn sugar. It's very, very bad for you. Switch to pure sugar - unrefined.
8) NO Partially Hydrogenated anything. This stuff is absolutely awful for anybody, but for pregnant women with clotting risk, this stuff is you enemy too.
9) No artificial sweeteners or diet sweeteners unless you are a diabetic and have no choice: most of them are harmful chemicals and neurotoxins... just get on sugar if you need something sweet because your body can process it with, of all the options, the least risk to your immune system.
10) Other nutrients and supplements: during your pregnancy, this would be iffy; but perhaps after the baby: consider Nattokinease or lubrokinnease: they are excellent.
11) If you toil with fibrinogen levels, consider Wobenzyne - discuss w/ your dr.
12) Look into probiotics: such as in yogurt or supplement form.

Good luck and I hope this gives you some good ideas.


PrincessB - March 13th, 2007 12:08 PM

[quote author=Miicki link=board=13;threadid=1981;start=510#33350 date=1173798113]
Who is in their last month of pregnancy? and if you are on lovenox now, have you switched to heparin or anything else prior to the birth? lastly- anyone not been diagnosed with a disorder & are using lovenox b/c that was kind of your last effort to sustain a pregnancy?

I am being switched to heparin- 2 Xs a day at 7500 at week 36. I have no known blood disorders or anything else wrong- just 4 m/c with no known reason after a lot of testing.

I just wanted to see what everyone else was doing for reference- My RE suggested this dosage to my OB/GYN.


Thanks
[/quote]

Okay: I tried writing a long response to this but it didn't take. I guess I was off longer than60 minutes. I will try again.

A medical journal reported that 5 in 100 are being diagnosed with HIT from Heparins (including Lovenox). HIT is Heparin-Induced Thrombocytopenia. They are discovering that it's pretty common - perhaps more common than their statistics. The HIT can be in the mother or baby. That statistic may increase as the medical community becomes more educated: not just Hematologists and Cardiologists but among Internal Medicine doctors and OBGYNs. For a mom with several heartbreaking miscarriages, these are still good odds when you've got a good Dr.

Here's what I understand the cautious OBs with lots of experience managing coagulation-challenged moms-to-be are doing: they are testing Lovenox levels all along, looking for signs of overdose. They use an anticoagulation approach until roughly 38 weeks - sometimes 39. According to the drs I have talked to, at that point the baby is "good to go" in most circumstances. An induction is performed, with an Rx coagulation taper 24-48 hours in advance. The fetal heart monitor is watched, with a doctor in the room at all times, if there is fetal distress, an emergency C-section is performed to protect the baby from IVCB - Intraventricular Cranial Bleeds (brain injury) or other complications that can arise also from natural childbirth if the infant has been Rx-exposed from a bleed. If HIT is discovered, such as in an infant, then transfusions over time should correct the HIT. There is enough post-marketing data on Lovenox and pregnancy to know that these complications can and do occur and therefore protecting mother and infant involve being very cautious about how and when to deliver, and how to control the delivery and coagulation so that you have the best possible chances for success.

I gave HopefulinNY some alternative coagulation management strategies that may be some for you to consider after your beautiful, healthy, perfect baby is born!!! God Bless!!

PS - if you have to stay on the RX, it is not recommended that you breast feed because it's not known if the Rx goes into the breast milk and you'll get a different answer depending on how much research you do and who you ask. If you want to breast feed, look at the alternative coagulation management strategies I gave HopefulinNY as discussion topics for you and your dr. !! Good Luck!! I'm hoping the best for you all!


concerned - March 13th, 2007 2:33 PM

In the last nine months I have had two miscarriages and in Jan. my doctor did various blood tests and came back to me simply saying get pregnant again go on baby aspirin for the first six weeks, get cardiac development and then we'll put you on lovenox. That's it. I am now 5 weeks pregnant again... I will go in for my u/s next week and hopefully hear a heartbeat.

I feel very unsure of what to ask and how to proceed- any advice as to specific questions I should ask assuming I hear a heartbeat and they prescribe lovenox.


Amanda - March 13th, 2007 9:37 PM

Hi everyone,

I'm new here and wanted to thank all of you for the information. I read through a lot of the posts and found a lot of great information.

I'm almost 27 and my husband and I have been trying to conceive for the past 4 months. We are hoping that this is our lucky month - I guess we'll find out in a couple of weeks!

In 10/2005 I had a blood clot in my head and ended up having a stroke because of it. The doctors' best guess is that the blood clot was from my birth control pill (Yasmin). I spent a week in the ICU and 2 more weeks in the inpatient rehab center of the hospital. I regained all of my function (speech, walking, writing, etc.) in that time - I was very lucky.

Since that time I have been told that I would have to be put on Lovenox during my pregnancies since my body doesn't seem to tolerate the surge in hormones very well. I've been taking my baby aspirin and folic acid everyday. I don't mind the thought of getting a shot everyday, but to actually do it myself is really scary. How do you all cope with that? I really don't know if I will be physically able to do this everyday. I can't wait to start my family, but I'm not looking forward to this "high risk" pregnancy. I'm terrified that somehow my child's life will be put at risk, either by the Lovenox or during delivery. My ob/gyn is great, and she has explained how I will have to go off of the Lovenox and be induced, etc., but I'm worried that there could be complications and somehow my child will suffer.

This site is wonderful. With all of the information out there, I have never had anyone to share all of these concerns with that actually understand them. So thank you to anyone who may be reading this or who can help ease my mind a little.

I'm anxiously awaiting the moment that I find out that I will be a mom, and I'm hoping that my body doesn't let me down this time.


Miicki - March 14th, 2007 11:25 AM

Concerned:
is there anything in your medical history/tests to say why you had an m/c? how old are you? i had no known reason for my m/c and i ending up trying lovenox b/c there was nothing else i could do- it is working--- i'd wait for the heartbeat first & then start the lovenox whenever the dr suggests. I started mine right after ovulation before i knew i was pregnant- maybe ask if that is a possibililty too-

Amanda: wow- you have been through a lot but recovered nicely- that is a true blessing. WHen i started lovenox I had my husband do it b/c there was no way i could give myself a shot either-- it freaked me out- he did it in my bottom for about the first 5 months--- then he had to go out of town & i had to do it- i started doing it in my thigh by myself and i can't believe i can do it but i can- so i'd try with your husband first just to get used to it & then try on your own when you are ready.... good luck


concerned - March 14th, 2007 1:22 PM

Thanks Miicki for your response apparently I just found out a new piece to the puzzle I have MTHFR? I am 28-- in the process of looking for a new doctor that will actually provide me with some info. rather than keep me in the dark like mine seems too. At this point I am already pregnant so I will just have to start lovenox next week like suggested assuming I don't miscarry again... we'll see. Any further suggestions of questions to ask. Princess B kind of freaked me out- does anyone know the statistics on kids being born healthy when the mother is taking lovenox?


Miicki - March 14th, 2007 5:28 PM

Several women on the site have MTHRF & you are young so that is good. Read back on some older pages & people discuss this--
I personally know of no one that's used Lovenox-- this site has been helpful for me & encouraging- i don't think i've read of anyone on lovenox that carried a baby to term & then ended up having disabilities. I think it's low odds--- A few more of us will know in a few more weeks--- I don't know the true statistics-- i'll see if i can find out..


Christy - March 14th, 2007 11:41 PM

I am new to this site. I am 21 weeks pregnant and have been on Lovenox for my whole pregnancy and before. We did IVF. My re said for me to stay on Lovenox throughout pregnancy. I have a MTHFR mutation.
My ob wanted me to go off it. So we went off it for a week and realized my re specializes in this and to go with his initial directions.

My question is this- we have been off it for a week, now we want to go back on. Does anyone know of any adverse reactions from going off then on again?
My re's office is not giving me any straight answers as they do not want to step on the toes of my obgyn (political thing, ob sends them many patients). I am frustrated. Has anyone gone off then on or have heard of this?
Thanks so much!


Miicki - March 15th, 2007 10:48 AM

Christy:
that would make me a little nervous. I can't believe your obgyn would have you go off it w/out consulting with the specialist first who put you on it---
I would make an appt w/the RE again & go in & discuss asap!!! i don't know of anyone that's gone off and gone back on- it's only been a week but i'm not a DR- this would be upsetting to me- but i know mistakes can happen- i would just want to correct it asap without any complications. Make the RE appt asap & have them sit down with you- political issue or not- you made the decision to go on it w/them & they need to help you..

tell us what happens---


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