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The original paper, "Mitochondria transfer from self-granular cells to improve embryos' quality" was published in February last year ('04). Unfortunately, the paper was published in Chinese (with an English summary), so it was impossible to carefully evaluate the authors methods and the study was limited to only 18 patients. The authors presented their findings at last year's ASRM meeting, but the author's capacity to speak English was very limited, so that didn't help clarify matters much either. Furthermore, isolation of mitochondria from granulosa cells involves a technique called sucrose density gradient ultracetrifugation and requires a research-grade centrifuge (worth about $150,000US). The equipment and facilities required to perform this kind of procedure are probably cost prohibitive for most IVF programs. Although the technique looks promising to treat women with defects of the egg cytoplasm (i.e. dark and grainy or "bull's eye appearance) it will not be effective in treating chromosomal abnormalities. In other words, you may be able to "rejuvinate" the cytoplasm of an geneticaly abnormal egg from an older woman by introducing "fresh" mitochondria at the time of ICSI, but the resulting embryo is still anueploid and will not develop to a term pregnancy.
Bottom line: interesting from an academic point of view, but not very practical in the clinical setting.
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