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chloe - April 16th, 2005 3:39 PM

Hi again,

During our last ICSI cycle 2 years ago - I developed hyperstimulation - my estrogen went very high and I had to coast at the end of the stimulation. We had 6 embryos but none kept dividing after 2 days. We suspect it was a cytoplasm problem due to suboptimal stimulation phase.

This time around I am at a new clinic. I will have the u/s and bloodwork more often to monitor the estrogen levels. My re stated that we have to be careful that we do not understimulate -

Q. What would your clinic do in these situations so I have an idea of what questions to ask/monitor? They suggested we meet with the embryologist just to establish a heads up. What do you think?

Thanks!

Dr Smith - April 18th, 2005 8:54 AM

Most of your questions should be directed towards Dr Jacob's Infertility 101 Message Board.

From the eggs and embryos point of view, it is essential that the eggs have the appropriate hormonal environment for maturation while in the follicle. This is achieved by ensuring the the hormonal environment during the stimulation and length of the stimulation are adjusted correctly. This requires frequent monitoring (US and bloodwork). OHSS causes a significant imbalance in the hormonal state and results in poor egg maturation and developmentally compromised embryos.

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