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I am 42 with history of very early miscarriages (1 natural, one after IUI and one after IVF, all on or around CD 37--PGD for my two IVF cycles indicated aneuploidy with approx 10/13 embryos). My husband has no male factor issues. I tested positive for PAI1 4g/5g polymorphism and have borderline low Protein S values. I started lovenox on 1/19. My LMP was 12/19, (natural cycle) I had a positive pregnancy test on the 17th. (I had some spotting on the 16th.) . HCG values:

1/17 52

1/19 171

1/22 560

1/24 696

1/27 746

My progesterone was initially low and I started injections on the 17th. the levels are now normal...

I know the pregnancy is probably not going to be viable.(is there any possiblity that the levels would "catch up"?)

what specifically in the development of the embryo is going on at this early stage that could cause this pattern?... I go back for one more level in 3 days and will come off the progesterone if no increase. What if the levels continue to rise very slowly? Would the progesterone be maintaining the pregnancy thus far? I have no spotting or cramping now at all.

Thanks very much for your input.

Michele

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