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Male Infertility Linked to Lupus Treatment - 06/29/2007

Sperm irregularities found in men with lupus may be connected to intravenous treatment involving immunosuppressant cyclophosphamide (IV CYC).

Brazilian researchers discovered the possible link after studying 25 men with systematic lupus erythematosus (SLE) and 35 healthy controls.

Researchers found that participants with SLE had a lower sperm count as well as lower sperm motility and volume compared to the participants who did not have the condition, as well as a lower normal sperm count.

SLE is an autoimmune disease that mostly affects women in their reproductive years, however it can also affect men. While concerns were expressed in the past regarding male fertility and SLE, this is the first study to conduct research regarding the relationship between systematic lupus erythematosus and testicular function and sperm abnormalities.

In addition, the study found that men with systematic lupus erythematosus who had more serious sperm irregularities had undergone more extensive treatment using IV CYC, suggesting a link between IV CYC treatment and male infertility caused by sperm damage.

Source: CBC.ca

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