Clomid and Thin Endometrium
The Difference Between A Thin And A Normal Endometrium
When a woman has thin endometrium, it means the lining of the uterus is insufficient to hold an egg once it becomes fertilized and is ready to implant in the womb and grow.
Should the egg manage to embed, it frequently is lost in a miscarriage resulting from intrauterine instability and a lack of tissue to hold the growing fetus.
Thin endometrium may also be a factor in poor placental development as well, which again, often ends in miscarriage.
A normal endometrium, or uterine lining, grows about one to two millimeters every day in response to estrogen and is usually about eight millimeters thick at the time of ovulation.
In an ultrasound, it is a good sign when the endometrium is marked by the three bright lines indicating a "grace-C" or trilaminar pattern. For a healthy pregnancy, it is important that the uterine lining is thick and strong.
Several factors affect the normal growth of the endometrium including infection, scarring from D&Cs, low estrogen levels, poor uterine blood supply or perhaps endometrial antibodies.
The Effects Of Clomid On The Uterine Lining
Often prescribed by generalists as a "first line" ovulation induction therapy, the goal of Clomid is to establish normal ovulation as opposed to causing the development of numerous mature eggs-which often happens with the use of Clomid.
Just as women's bodies are very different from one another, so are the responses to Clomid. Some women have no side effects from the drug, while others suffer any number of disturbances both physically and mentally. Hot flashes, sore breasts, nausea and vomiting and abnormal uterine bleeding are a few of the side effects noted by users of Clomid.
Clomid, an anti-estrogen drug, can block the stimulation of estrogen on the uterine lining and what results is a thin uterine lining. Clomid is made up of two isomers. One of the isomers leaves the body within a week of cessation and the other remains in the body for up to six weeks, causing an anti-estrogen effect.
Using Clomid for more than three months consecutively will almost assuredly result in a thinning of the endometrium. Age causes a natural thinning of the uterine lining which is why women over the age of 40 rarely conceive on Clomid. Clomid can, after prolonged use, reverse its effects and act as a contraceptive regardless of the age or ovarian response of the woman.
In order to eliminate all of the anti-estrogen isomer from the system, it is important to discontinue use of Clomid for a period of six weeks.
Thinning Endometrium Is An Indicator Of A Problem
It is important to note that thin endometrium is a finding and not a disease, syndrome or condition. Because of this fact, there are few research papers available on the subject.
It appears that thin endometrium is caused by something specific outside of being a syndrome on its own and hence it is advisable that medical practitioners find the root cause and treat it rather than trying to treat thin uterine lining.